Mudunuru Aswin Kumar, Valipay Kartik, Rahman Arifa, Bomma Sailaja, Jahnavi Lalitha V, Reddy M S
Non-Invasive Brain Stimulation, Asha Neuromodulation Clinics, Hyderabad, IND.
Psychiatry, Asha Neuromodulation Clinics, Hyderabad, IND.
Cureus. 2025 Jul 31;17(7):e89177. doi: 10.7759/cureus.89177. eCollection 2025 Jul.
Idiopathic Normal Pressure Hydrocephalus (iNPH) is a rare syndrome of apractic or ataxic gait, mild to moderate dementia, and urinary incontinence. The cerebrospinal fluid tap test is widely used in the diagnosis of NPH. Using deep Transcranial Magnetic Simulation (DTMS) with H coils, we developed a novel treatment method that incorporates electroencephalography (EEG)-based customization of the treatment protocol. An 80-year-old male presented with clinical signs of slowness of gait and activity, rigidity, and urinary incontinence, which progressed to bradykinesia, magnetic, short, and shuffling gait. He later developed altered behavior, memory loss, and cognitive deficit. Administration of 17 DTMS sessions with an H4 coil provided transient relief from a few symptoms for approximately two months. Fast Fourier transform analysis of the frontal EEG was used to find the peak activity and customize the treatment protocol. Eleven DTMS sessions with optimized protocol gave a sustainable symptomatic relief as well as improved functionality, as estimated on 10-month follow-up.
特发性正常压力脑积水(iNPH)是一种罕见的综合征,表现为失用或共济失调步态、轻至中度痴呆以及尿失禁。脑脊液引流试验广泛应用于NPH的诊断。我们使用H型线圈进行深部经颅磁刺激(DTMS),开发了一种基于脑电图(EEG)定制治疗方案的新型治疗方法。一名80岁男性出现步态和活动迟缓、僵硬以及尿失禁的临床症状,随后发展为运动迟缓、磁性、短小和拖曳步态。他后来出现行为改变、记忆力减退和认知缺陷。使用H4型线圈进行17次DTMS治疗,使一些症状得到了约两个月的短暂缓解。通过对额叶脑电图进行快速傅里叶变换分析来找到峰值活动并定制治疗方案。在10个月的随访中评估,采用优化方案进行的11次DTMS治疗带来了持续的症状缓解以及功能改善。