Allam Priscilla, Farishta Faraz
Internal Medicine, Care Hospitals, Hyderabad, IND.
Endocrinology, Diabetes and Metabolism, FS Endocrine and Diabetes Center, Hyderabad, IND.
Cureus. 2025 Jul 29;17(7):e89014. doi: 10.7759/cureus.89014. eCollection 2025 Jul.
Background Chronic kidney disease has been found to increase the risk of cardiovascular disease (CVD). Carotid intima media thickness (CIMT) is a commonly used surrogate marker for assessing atherosclerosis. Recent interest has emerged in exploring the potential of calcium phosphate product (Ca x Pi) as an alternative or adjunct in evaluating cardiovascular risk in these patients. This study aimed to find the correlation between Ca x Pi and CIMT in patients with advanced chronic kidney disease. Methods A cross-sectional study was conducted at Thumbay Hospital New Life, Hyderabad, from January 2020 to December 2020. Fifty patients with advanced chronic kidney disease (stages 3 and above) were included after applying the inclusion and exclusion criteria. Serum Ca x Pi levels were measured along with CIMT using carotid ultrasound. Statistical analysis was performed to assess the correlation between Ca x Pi and CIMT. Results The mean Ca x Pi was 44.8±11, and the mean CIMT was 1.68±0.47 mm. A positive correlation was found between Ca x Pi and CIMT (p = 0.03), while serum phosphorus showed a strong correlation with CIMT (p < 0.01). Conclusion Ca x Pi shows promise as a surrogate marker for assessing cardiovascular risk in patients with chronic kidney disease, alongside CIMT. Further research, including larger longitudinal studies, is warranted to validate these findings and explore the utility of Ca x Pi in clinical practice.
背景 慢性肾脏病已被发现会增加心血管疾病（CVD）的风险。颈动脉内膜中层厚度（CIMT）是评估动脉粥样硬化常用的替代标志物。最近，人们开始关注探索磷酸钙乘积（Ca×Pi）作为评估这些患者心血管风险的替代指标或辅助指标的潜力。本研究旨在探讨晚期慢性肾脏病患者中Ca×Pi与CIMT之间的相关性。方法 于2020年1月至2020年12月在海得拉巴的Thumbay医院新生活院区进行了一项横断面研究。在应用纳入和排除标准后，纳入了50例晚期慢性肾脏病（3期及以上）患者。使用颈动脉超声测量血清Ca×Pi水平以及CIMT。进行统计分析以评估Ca×Pi与CIMT之间的相关性。结果 Ca×Pi的平均值为44.8±11，CIMT的平均值为1.68±0.47mm。发现Ca×Pi与CIMT之间存在正相关（p = 0.03），而血清磷与CIMT之间存在强相关（p < 0.01）。结论 Ca×Pi有望作为评估慢性肾脏病患者心血管风险的替代标志物，与CIMT一起使用。需要进一步的研究，包括更大规模的纵向研究，以验证这些发现并探索Ca×Pi在临床实践中的实用性。
