钙磷酸盐产品与 2 型糖尿病患者的亚临床颈动脉粥样硬化相关。
Calcium Phosphate Product Is Associated with Subclinical Carotid Atherosclerosis in Type 2 Diabetes.
机构信息
Health Sciences Research Institute Germans Trias i Pujol, Camí de les Escoles S/N, 08916 Badalona, Spain.
Department of Endocrinology and Nutrition, Health Sciences Research Institute and University Hospital Germans Trias i Pujol, Carretera Canyet S/N, 08916 Badalona, Spain.
出版信息
J Diabetes Res. 2017;2017:3498368. doi: 10.1155/2017/3498368. Epub 2017 Aug 3.
AIMS
To assess whether circulating 25-hydroxyvitamin D (25OHD) and mineral metabolism-related factors (serum phosphate, calcium, and parathormone) are associated with subclinical carotid atherosclerosis (SCA), defined as the presence of carotid atherosclerotic plaques (main study outcome), in patients with type 2 diabetes mellitus (T2DM) without kidney disease or previous cardiovascular disease.
METHODS
We undertook a post hoc analysis of a cross-sectional study in adults with T2DM in whom we evaluated SCA. A total of 303 subjects with T2DM were included. Clinical variables and carotid ultrasound imaging were obtained.
RESULTS
We found no association of 25OHD with the presence of SCA. However, calcium phosphate (CaP; mg/dL) product was positively associated with the presence of carotid plaques (OR = 1.078; 95% CI: 1.017-1.142). An inverse association was observed between higher levels of 25OHD (≥30 ng/mL versus <20 ng/mL concentrations) and common carotid intima-media thickness (cIMT; mm) ( ± SE = -0.055 ± 0.024). We conclude that the CaP product is independently associated with the presence of established subclinical carotid atherosclerosis in patients with T2DM.
目的
评估 25-羟维生素 D（25OHD）和矿物质代谢相关因素（血清磷酸盐、钙和甲状旁腺激素）是否与 2 型糖尿病（T2DM）患者的亚临床颈动脉粥样硬化（SCA）相关，SCA 定义为存在颈动脉粥样硬化斑块（主要研究结局），这些患者无肾脏疾病或既往心血管疾病。
方法
我们对一项横断面研究进行了事后分析，该研究纳入了成年人 T2DM 患者，我们评估了 SCA。共纳入 303 例 T2DM 患者。获取临床变量和颈动脉超声影像学资料。
结果
我们发现 25OHD 与 SCA 的发生无相关性。然而，钙磷（CaP；mg/dL）乘积与颈动脉斑块的存在呈正相关（OR=1.078；95%CI：1.017-1.142）。较高的 25OHD 水平（≥30ng/mL 与 <20ng/mL 浓度）与颈总动脉内膜-中层厚度（cIMT；mm）呈负相关（ ± SE=−0.055 ± 0.024）。我们的结论是，CaP 产物与 T2DM 患者已确立的亚临床颈动脉粥样硬化的发生独立相关。
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