Carter Robert E, Denning Krista L, Goebel Lynne J
Internal Medicine, Joan C. Edwards School of Medicine at Marshall University, Huntington, USA.
Pathology, Joan C. Edwards School of Medicine at Marshall University, Huntington, USA.
Cureus. 2025 Jul 31;17(7):e89143. doi: 10.7759/cureus.89143. eCollection 2025 Jul.
Pulmonary sarcomatoid carcinoma (PSC) is a rare, aggressive cancer with early metastasis and poor prognosis. Chest X-ray and computed tomography (CT) are common modalities used to detect malignancy, and the diagnosis is confirmed with tissue biopsy. There are currently no guidelines for therapy when treating this condition as it often displays resistance to typical first-line chemotherapy agents. We present a case of PSC with brain metastasis and our approach to management to remind clinicians of this rare condition and the limited choices of treatment.
肺肉瘤样癌(PSC)是一种罕见的侵袭性癌症,早期易发生转移,预后较差。胸部X线和计算机断层扫描(CT)是用于检测恶性肿瘤的常见手段,通过组织活检确诊。由于这种疾病通常对典型的一线化疗药物耐药,目前在治疗时没有相关指南。我们报告一例伴有脑转移的PSC病例以及我们的治疗方法,以提醒临床医生注意这种罕见疾病及其有限的治疗选择。