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皮肤癌肉瘤:一个小病例系列及对一种罕见皮肤肿瘤的文献综述

Cutaneous Carcinosarcoma: A Small Case Series and Review of the Literature of a Rare Skin Tumor.

作者信息

Song Ethan Y, Wallace Sean J, Sheikh Hina, Wojcik Randolph, Nayak Chetan

机构信息

Plastic and Reconstructive Surgery, University of South Florida Morsani College of Medicine, Tampa, USA.

Division of Plastic & Reconstructive Surgery, Lehigh Valley Health Network, Allentown, USA.

出版信息

Cureus. 2020 Aug 5;12(8):e9569. doi: 10.7759/cureus.9569.

Abstract

Carcinosarcomas are composed of epithelial and mesenchymal elements and primarily present within visceral organs. Despite being potentially aggressive, they are a rare diagnosis in the skin, and few manifestations have been reported to date. In this report, we describe two separate cases of carcinosarcoma presenting as nonhealing scalp wounds. Patient A: a 57-year-old male with a nonhealing skin lesion of ten years successfully treated with wide-local excision and local ortichochea flap reconstruction. Patient B: a 75-year-old female that presented with a painless, slow-growing hemorrhagic mass of 7 years invading the skull and dura ultimately requiring craniectomy and free-tissue transfer with anterolateral thigh flap. Cutaneous carcinosarcomas have more favorable outcomes due to low metastatic rates likely due to earlier detection, but delayed presentation can be fatal. Histopathological analysis is critical for determining diagnosis and prognosis. Adequate reconstruction after wide base excision varies and follows the reconstructive ladder/elevator ranging from primary closure up through free-tissue transfer. With cutaneous manifestations of carcinosarcoma seldom reported in the literature, it is our hope that reporting unusual instances such as this will raise awareness and allow for earlier diagnoses, treatments, and reconstructions.

摘要

癌肉瘤由上皮和间充质成分组成,主要出现在内脏器官。尽管具有潜在侵袭性,但它们在皮肤中是罕见的诊断,迄今为止报道的表现很少。在本报告中,我们描述了两例表现为头皮伤口不愈合的癌肉瘤病例。患者A:一名57岁男性,有一个十年不愈合的皮肤病变,通过广泛局部切除和局部奥蒂乔查皮瓣重建成功治疗。患者B:一名75岁女性,出现一个7年无痛、生长缓慢的出血性肿块,侵犯颅骨和硬脑膜,最终需要颅骨切除术和带股前外侧皮瓣的游离组织移植。皮肤癌肉瘤由于转移率低可能因早期发现而有更有利的结果,但延迟表现可能是致命的。组织病理学分析对于确定诊断和预后至关重要。广泛基底切除后的充分重建各不相同,遵循从一期缝合到游离组织移植的重建阶梯/电梯。鉴于癌肉瘤的皮肤表现很少在文献中报道,我们希望报告这样的不寻常病例将提高认识,并允许更早的诊断、治疗和重建。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f8e/7474563/4c502ab97861/cureus-0012-00000009569-i01.jpg

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