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英国成人注意力缺陷多动障碍(ADHD)中延迟睡眠发作管理的最佳护理系统:改良德尔菲共识法

The optimal system of care for the management of delayed sleep onset in adult ADHD in the UK: a modified Delphi consensus.

作者信息

Asherson Philip, Giaroli Giovanni, Gringras Paul, Phillips Heidi, Selsick Hugh, Smith Michael, Hank Dietmar

机构信息

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, United Kingdom.

The Giroli Centre, London, United Kingdom.

出版信息

Front Psychiatry. 2025 Aug 14;16:1566390. doi: 10.3389/fpsyt.2025.1566390. eCollection 2025.

Abstract

INTRODUCTION

Sleep-related disorders affect a significant number of individuals with ADHD, the most common of which has been found to be delayed sleep phase syndrome/delayed sleep onset. The presence of a sleep disorder can exacerbate ADHD symptoms and impair cognitive functions. Despite the significance of these issues, they are often overlooked, potentially leading to unsafe self-medication practices and illicit substance abuse. While the literature supports the efficacy of melatonin in treating delayed sleep onset among children and adolescents with ADHD, evidence in adults is less well-established. This consensus study aims to establish consensus among healthcare professionals regarding the overall management of adults with ADHD experiencing delayed sleep onset in the UK, with the aim of guiding good clinical practice.

METHODS

The process employed a modified Delphi methodology. A literature review was conducted to understand the current evidence base. A steering group of seven experts from the UK attended a virtual meeting in April 2024. During this meeting, facilitated by an independent moderator, the group identified six primary domains. Based on these domains, 40 statements were developed into an online survey for testing with a wider panel of peers.Stopping criteria for consensus rounds were established as a survey duration of four months, a target of 200 responses, and the requirement that at least 90% of the statements achieve the consensus threshold of ≥75% agreement.

RESULTS

A total of 212 responses were received from healthcare professionals experienced in managing adult patients with ADHD and sleep disorders in the UK. All proposed statements achieved consensus, with 90% of statements achieved ≥90% agreement (n=36/40).

CONCLUSION

Based on the agreement levels achieved, the steering group developed a series of recommendations for the management of delayed sleep onset in adult ADHD in the UK. Given the prevalence of sleep disorders in this population, a comprehensive management approach is essential. This should include effective treatments, such as melatonin, which could be initiated in primary care and monitored by general practitioners for newly diagnosed patients. It is also important that treatment for delayed sleep onset is continued as individuals transition from childhood into adulthood.

摘要

引言

与睡眠相关的障碍影响着大量患有注意力缺陷多动障碍(ADHD)的个体,其中最常见的被发现是睡眠相位延迟综合征/入睡延迟。睡眠障碍的存在会加重ADHD症状并损害认知功能。尽管这些问题很重要,但它们常常被忽视,这可能导致不安全的自我用药行为和非法药物滥用。虽然文献支持褪黑素在治疗患有ADHD的儿童和青少年入睡延迟方面的疗效,但在成人中的证据尚不充分。这项共识研究旨在就英国患有ADHD且入睡延迟的成人的整体管理在医疗保健专业人员中达成共识,以指导良好的临床实践。

方法

该过程采用了改良的德尔菲方法。进行了文献综述以了解当前的证据基础。由来自英国的七位专家组成的指导小组于2024年4月参加了一次虚拟会议。在这次由独立主持人主持的会议期间,该小组确定了六个主要领域。基于这些领域,制定了40条陈述并形成一项在线调查,以供更广泛的同行群体进行测试。共识轮次的停止标准设定为调查为期四个月、目标回复量为200份,并且要求至少90%的陈述达到≥75%同意的共识阈值。

结果

共收到来自英国在管理患有ADHD和睡眠障碍的成年患者方面经验丰富的医疗保健专业人员的212份回复。所有提出的陈述都达成了共识,90%的陈述达成了≥90%的同意率(n = 36/40)。

结论

基于所达成的同意水平,指导小组为英国成人ADHD入睡延迟的管理制定了一系列建议。鉴于该人群中睡眠障碍的患病率,全面的管理方法至关重要。这应包括有效的治疗方法,如褪黑素,可在初级保健中启动并由全科医生对新诊断患者进行监测。随着个体从儿童期过渡到成年期,持续治疗入睡延迟也很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/12392164/ce19ffe6f687/fpsyt-16-1566390-g001.jpg

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