Cardillo Ramona, Di Modica Irene, Cucinotta Francesca, Galletta Federica, Raffagnato Alessia, Di Cara Marcella, De Domenico Carmela, Germanò Eva, Carucci Sara, Abbracciavento Giuseppe, Murtas Rita, Donia Alessia, Bonelli Giuliana, Grittani Serenella, Lanzarini Evamaria, Accetta Arianna, Pirrone Martina, Costanza Carola, Siracusano Rosamaria, Cedro Clemente, Gatta Michela, Gagliano Antonella
Department of Developmental Psychology and Socialization, University of Padua, Padua, Italy.
Child and Adolescent Neuropsychiatry Unit, Department of Women's and Children's Health, Padua University Hospital, Padua, Italy.
Front Psychiatry. 2025 Aug 15;16:1614270. doi: 10.3389/fpsyt.2025.1614270. eCollection 2025.
Suicidal spectrum behaviors (SSB) consist of a continuum ranging from non suicidal self-injury, suicidal ideation, and suicide attempt to committed suicide. In adolescence, suicide is currently the second cause of death among adolescents aged 15 to 24 years and the third leading cause in children aged 10 to 14 years. Adolescents with Neurodevelopmental Disorders (NDDs), especially those with Autism Spectrum Disorder and Attention Deficit/Hyperactivity Disorder, are at heightened risk.
This is a cross-sectional, multicenter research study, which involves four Italian child neuropsychiatry units (Messina, Padua, Rimini, and Cagliari). The study aims to define a specific neuropsychological and psychopathological profile associated with suicidal behaviors in adolescents and pre-adolescents with NDDs (11-18 years). In a sample of 127 NDDs adolescents (60 females and 67 males), with and without SSB, several variables were compared through standardized measures, including emotional dysregulation, impulsivity, and irritability as well as environmental risk factors.
The results of this study are consistent with the literature data and suggest that emotional dysregulation (p <.001) as an individual factor and Adverse Childhood Experiences (p = .002), as environmental factors, play a key role in promoting suicidality in pre-adolescents and adolescents with NDDs.
This awareness prompts the implementation of useful prevention methods during the clinical follow-up of individuals with NDDs.
自杀谱系行为（SSB）包括一个连续体，范围从非自杀性自伤、自杀意念、自杀未遂到自杀身亡。在青少年中，自杀目前是15至24岁青少年的第二大死因，是10至14岁儿童的第三大死因。患有神经发育障碍（NDDs）的青少年，尤其是患有自闭症谱系障碍和注意力缺陷/多动障碍的青少年，风险更高。
这是一项横断面多中心研究，涉及四个意大利儿童神经精神病学单位（墨西拿、帕多瓦、里米尼和卡利亚里）。该研究旨在确定与患有NDDs（11 - 18岁）的青少年和青春期前儿童自杀行为相关的特定神经心理学和精神病理学特征。在127名患有NDDs的青少年（60名女性和67名男性）样本中，有或无SSB，通过标准化测量比较了几个变量，包括情绪失调、冲动性和易怒性以及环境风险因素。
本研究结果与文献数据一致，表明情绪失调（p <.001）作为个体因素和童年不良经历（p =.002）作为环境因素，在促进患有NDDs的青春期前儿童和青少年自杀方面起关键作用。
这种认识促使在对患有NDDs的个体进行临床随访期间实施有用的预防方法。
