Centeno Gavica Jenifer, Thapa Rupak
Department of Rheumatology, Atrium Health Wake Forest Baptist, Winston Salem, NC, USA.
J Scleroderma Relat Disord. 2025 Aug 30:23971983251370102. doi: 10.1177/23971983251370102.
SclerEDEMA is a rare condition marked by diffuse skin thickening, often confused with sclerODERMA. It is linked with infections, malignancies, and diabetes. Although scleredema is associated with hematologic malignancies like multiple myeloma, it has not been reported with breast cancer, as suspected in this patient. We present a case of a patient diagnosed with scleredema, confirmed through skin biopsy. Subsequent cancer screenings identified a 6 mm breast nodule, which was confirmed as grade 3 ductal carcinoma. This newfound association between scleredema and breast cancer highlights the importance of vigilant health maintenance and regular cancer screenings in these patients.
硬化性水肿是一种罕见病症,其特征为皮肤弥漫性增厚,常与硬皮病相混淆。它与感染、恶性肿瘤及糖尿病有关。尽管硬化性水肿与多发性骨髓瘤等血液系统恶性肿瘤相关,但如该患者所怀疑的那样,尚未有与乳腺癌相关的报道。我们报告一例经皮肤活检确诊为硬化性水肿的患者。随后的癌症筛查发现一个6毫米的乳腺结节,确诊为3级导管癌。硬化性水肿与乳腺癌之间这种新发现的关联凸显了对这些患者进行警惕的健康维护和定期癌症筛查的重要性。