Guo Qi, Shi Dai, Li Guilai, Liu Yue, Xu Guoping
Department of Radiology, Second Hospital of Tianjin Medical University, Tianjin, China.
Department of Radiology, Second Affiliated Hospital of Soochow University, Suzhou, China.
Front Oncol. 2025 Aug 14;15:1654218. doi: 10.3389/fonc.2025.1654218. eCollection 2025.
Primary adrenal melanoma is an exceedingly rare diagnosis. We present a case of primary left adrenal melanoma with rapid and extensive distant metastasis. The patient underwent a biopsy of the left adrenal tumor, and pathological analysis confirmed malignant melanoma. Immunohistochemical staining revealed positive cytoplasmic reactivity for Melan A, HMB45, and SOX-10. We also review relevant cases reported in the English literature and discuss the diagnostic criteria, differential diagnoses, and potential management strategies.
原发性肾上腺黑色素瘤是一种极其罕见的诊断。我们报告一例原发性左肾上腺黑色素瘤伴快速广泛远处转移的病例。患者接受了左肾上腺肿瘤活检，病理分析证实为恶性黑色素瘤。免疫组化染色显示Melan A、HMB45和SOX-10的细胞质反应呈阳性。我们还回顾了英文文献中报道的相关病例，并讨论了诊断标准、鉴别诊断和潜在的治疗策略。
