Wan Mengliao, Yin Yulong, Duan Yehui, Chen Jiashun
Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China.
College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Anim Nutr. 2025 Jul 11;22:375-383. doi: 10.1016/j.aninu.2025.06.001. eCollection 2025 Sep.
Methionine (Met) is the only sulfur-containing essential amino acid for animals and is the second or third limiting amino acid in swine diets. It plays a role not only in protein synthesis, but also as an important methyl donor to participate in various biochemical reactions. Additionally, Met can be converted into several functional derivatives, such as S-adenosylmethionine (SAM) and homocysteine (Hcy) through which it exerts its biological functions. Specifically, appropriate supplementation with Met or SAM has been shown to provide a wide range of health-promoting effects, particularly in enhancing reproductive performance, improving intestinal morphology, regulating hepatic lipid metabolism, promoting muscle growth, and improving meat quality. In contrast, elevated Hcy levels can increase oxidative stress and inflammation, negatively affecting reproductive performance. Supplemental Met has been widely used in swine production for many years. This review summarizes recent advances in the application of Met and its derivatives in the pig industry, and explores their mechanism of action and optimal dosage as a feed additive, aiming to support the effective development and rational use of Met.
蛋氨酸（Met）是动物唯一含硫的必需氨基酸，是猪日粮中的第二或第三限制性氨基酸。它不仅在蛋白质合成中起作用，还作为重要的甲基供体参与各种生化反应。此外，蛋氨酸可转化为多种功能性衍生物，如S-腺苷甲硫氨酸（SAM）和同型半胱氨酸（Hcy），并通过它们发挥生物学功能。具体而言，适当补充蛋氨酸或S-腺苷甲硫氨酸已显示出广泛的健康促进作用，特别是在提高繁殖性能、改善肠道形态、调节肝脏脂质代谢、促进肌肉生长和改善肉质方面。相比之下，同型半胱氨酸水平升高会增加氧化应激和炎症，对繁殖性能产生负面影响。多年来，蛋氨酸补充剂已广泛应用于养猪生产。本文综述了蛋氨酸及其衍生物在养猪业应用的最新进展，并探讨了它们作为饲料添加剂的作用机制和最佳剂量，旨在支持蛋氨酸的有效开发和合理使用。
