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虾青素通过修复肠道屏障、调节特定肠道菌群和减少炎症细胞浸润来减轻葡聚糖硫酸钠诱导的小鼠结肠炎。

Astaxanthin Mitigates Dextran Sulfate Sodium-Induced Colitis in Mice by Repairing the Intestinal Barrier, Regulating Specific Intestinal Flora, and Reducing Inflammatory Cell Infiltration.

作者信息

Shen Guangzhe, Yu Du, Xu Longfei, Yang Tiezheng

机构信息

Anorectal Department, First Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun 130021, China.

出版信息

J Immunol Res. 2025 Aug 21;2025:3381950. doi: 10.1155/jimr/3381950. eCollection 2025.

DOI:10.1155/jimr/3381950
PMID:40896793
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12393947/
Abstract

As a dietary supplement for humans and animals, Astaxanthin (Ax) is widely believed to possess antioxidant and anti-inflammatory properties. In this study, we attempted to evaluate the protective effects of Ax on dextran sodium sulfate (DSS)-induced colitis in mice and the underlying molecular mechanism. Our results suggested that Ax significantly reduced the severity of DSS-induced colitis in mice, as evidenced by increased colon length, decreased disease activity index (DAI), and attenuated inflammatory factors. In addition, Ax significantly increased the diversity of gut microbiota in mice with colitis, remodeled the microbial composition, promoted the production of beneficial bacteria (e.g., Lactobacillaceae), and inhibited the production of harmful bacteria (e.g., Lachnospiraceae and Muribaculaceae). In conclusion, Ax alleviated DSS-induced colitis by maintaining the intestinal barrier and regulating intestinal microbes.

摘要

作为人和动物的膳食补充剂，虾青素（Ax）被广泛认为具有抗氧化和抗炎特性。在本研究中，我们试图评估Ax对葡聚糖硫酸钠（DSS）诱导的小鼠结肠炎的保护作用及其潜在的分子机制。我们的结果表明，Ax显著降低了DSS诱导的小鼠结肠炎的严重程度，这通过结肠长度增加、疾病活动指数（DAI）降低和炎症因子减轻得到证明。此外，Ax显著增加了结肠炎小鼠肠道微生物群的多样性，重塑了微生物组成，促进了有益细菌（如乳酸杆菌科）的产生，并抑制了有害细菌（如毛螺菌科和拟杆菌科）的产生。总之，Ax通过维持肠道屏障和调节肠道微生物来减轻DSS诱导的结肠炎。

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本文引用的文献

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Food Funct. 2024 Apr 22;15(8):4207-4222. doi: 10.1039/d4fo00610k.
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Phlorizin Mitigates Dextran Sulfate Sodium-Induced Colitis in Mice by Modulating Gut Microbiota and Inhibiting Ferroptosis.根皮苷通过调节肠道微生物群和抑制铁死亡减轻葡聚糖硫酸钠诱导的小鼠结肠炎。
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Deferasirox alleviates DSS-induced ulcerative colitis in mice by inhibiting ferroptosis and improving intestinal microbiota.
地拉罗司通过抑制铁死亡和改善肠道微生物群来减轻右旋糖酐硫酸钠诱导的小鼠溃疡性结肠炎。
Life Sci. 2023 Feb 1;314:121312. doi: 10.1016/j.lfs.2022.121312. Epub 2022 Dec 21.
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Orally Administered Ginkgolide C Attenuates DSS-Induced Colitis by Maintaining Gut Barrier Integrity, Inhibiting Inflammatory Responses, and Regulating Intestinal Flora.口服银杏内酯 C 通过维持肠道屏障完整性、抑制炎症反应和调节肠道菌群来减轻 DSS 诱导的结肠炎。
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The Gut Microbiota in Inflammatory Bowel Disease.肠道微生物群与炎症性肠病。
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