Nishida Yasuhiro, Nawaz Allah, Hecht Karen, Tobe Kazuyuki
First Department of Internal Medicine, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Fuji Chemical Industries, Co., Ltd., 55 Yokohoonji, Kamiich-machi, Nakaniikawa-gun, Toyama 930-0405, Japan.
Nutrients. 2021 Dec 27;14(1):107. doi: 10.3390/nu14010107.
Astaxanthin is a member of the carotenoid family that is found abundantly in marine organisms, and has been gaining attention in recent years due to its varied biological/physiological activities. It has been reported that astaxanthin functions both as a pigment, and as an antioxidant with superior free radical quenching capacity. We recently reported that astaxanthin modulated mitochondrial functions by a novel mechanism independent of its antioxidant function. In this paper, we review astaxanthin's well-known antioxidant activity, and expand on astaxanthin's lesser-known molecular targets, and its role in mitochondrial energy metabolism.
虾青素是类胡萝卜素家族的一员，在海洋生物中大量存在，近年来因其多样的生物/生理活性而受到关注。据报道，虾青素既作为一种色素发挥作用，又作为一种具有卓越自由基淬灭能力的抗氧化剂。我们最近报道，虾青素通过一种独立于其抗氧化功能的新机制调节线粒体功能。在本文中，我们回顾了虾青素广为人知的抗氧化活性，并详细阐述了虾青素鲜为人知的分子靶点及其在线粒体能量代谢中的作用。
