Uddin Md Nasir, Kabir Shahanaz, Khan M Azizur R, Ullah Muhammad Wajid, Hoque Md Anamul, Anis-Ul-Haque K M, Gatasheh Mansour K
Department of Chemistry, Jashore University of Science and Technology, Jashore 7408, Bangladesh.
Department of Pulp & Paper Engineering, College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
Int J Biol Macromol. 2025 Aug 31;328(Pt 1):147265. doi: 10.1016/j.ijbiomac.2025.147265.
β-cyclodextrin (β-CD) is a macromolecule belonging to the class of cyclic oligosaccharides and is employed across diverse fields including the pharmaceuticals, food, and cosmetics, environment and agrochemical industries. This study examined the competitive interplay between micellization and host-guest complexation between the anionic surfactant sodium dodecyl sulfate (SDS) and β-cyclodextrin (β-CD). The effect of sodium-based electrolytes and temperature was thoroughly investigated within the SDS@β-CD mixed system. FTIR and SEM analyses indicates the creation of a host-guest inclusion complex, with β-CD acting as the host and SDS as the guest. Conductometric analysis revealed that the β-CD greatly inhibits the micellization of the SDS, resulting in an increased critical micelle concentration (CMC) in water environment, while presence of sodium salts (NaBr/ NaSO/ NaPO/ NaOAc (sodium acetate)) counteract this inhibition, promoting micellization and lowering the CMC. This salt effect is consistent with the Hofmeister series of ions based on the hydrophobic interactions within SDS@β-CD system and is influenced by the temperature. The magnitude of thermodynamic parameters (∆G, ∆H, ∆S) indicates a spontaneous micellization process, which is driven by only entropic contributions at lower temperatures as well as joint contributions from enthalpy and entropy at higher temperatures. The findings of this study provide valuable insights into how cyclodextrins (CDs) and electrolytes can be used to fine-tune surfactant self-assembly, with implications for designing responsive systems in drug delivery, materials science, and industrial formulations.
β-环糊精（β-CD）是一种属于环状寡糖类的大分子，广泛应用于制药、食品、化妆品、环境和农用化学品等多个领域。本研究考察了阴离子表面活性剂十二烷基硫酸钠（SDS）与β-环糊精（β-CD）之间胶束化和主客体络合的竞争相互作用。在SDS@β-CD混合体系中深入研究了钠基电解质和温度的影响。傅里叶变换红外光谱（FTIR）和扫描电子显微镜（SEM）分析表明形成了主客体包合物，其中β-CD作为主体，SDS作为客体。电导分析表明，β-CD极大地抑制了SDS的胶束化，导致在水环境中临界胶束浓度（CMC）增加，而钠盐（NaBr/NaSO/NaPO/NaOAc（醋酸钠））的存在抵消了这种抑制作用，促进了胶束化并降低了CMC。这种盐效应与基于SDS@β-CD体系内疏水相互作用的霍夫迈斯特离子序列一致，并受温度影响。热力学参数（∆G、∆H、∆S）的大小表明胶束化过程是自发的，在较低温度下仅由熵贡献驱动，而在较高温度下由焓和熵共同贡献驱动。本研究结果为环糊精（CDs）和电解质如何用于微调表面活性剂自组装提供了有价值的见解，对药物递送、材料科学和工业配方中响应系统的设计具有重要意义。
