Ahmed Bulbul, Hasan Tajmul, Hasan Kamrul, Khan Javed Masood, Kumar Dileep, Mahbub Shamim, Goni Md Abdul, Hoque Md Anamul
Department of Chemistry, Jahangirnagar University, Savar, Dhaka, 1342, Bangladesh.
Department of Chemistry, Bangladesh Army University of Science and Technology Khulna, Khulna, 9204, Bangladesh.
Sci Rep. 2025 Aug 13;15(1):29695. doi: 10.1038/s41598-025-88274-z.
The investigation of the impact of different additives on the aggregation behavior of drug-surfactant mixtures is highly important to improve pharmaceutical formulations. This study reveals the micellization characteristics of sodium dodecyl sulfate (NaDS) with ofloxacin (OFC) drug different pH and in the occurrence of different electrolytes (KCl, KNO, KHSO, and KSO) media at temperatures from 298.15 to 323.15 K. The critical micelle concentration (CMC), the extent of ionization (α), and the degree of counterion binding (β) have been evaluated for the NaDS and OFC system using the conductometric method. The CMC values are found to decline with uprising of salts contents which exposes the favorable micellization in the attendance of employed salts. The CMC values experience an enhancement as the experimental temperatures increased in all electrolyte's solutions. The Gibbs free energy [Formula: see text] values of NaDS + OFC system in aq. K-based electrolytes media have been appeared as negative indicating a spontaneous association of the system. The changes of enthalpy ([Formula: see text]), and entropy ([Formula: see text]) reveal that hydrophobic and electrostatic interactions are the interaction forces between components in aq. electrolytes media. The thermodynamics properties of transfer ([Formula: see text], [Formula: see text], [Formula: see text]), molar heat capacity [Formula: see text] compensation temperature (T) along with the intrinsic enthalpy gain ([Formula: see text]) were also calculated and the results were discussed accordingly. Moreover, UV-Visible spectroscopic technique was used to determine various significant parameters including binding constant (K), partition constant (K), partition coefficient (K), Gibbs energy of binding (ΔG), and Gibbs energy of partition (ΔG) for the mixtures of NaDS and OFC in aqueous and aq. salt solutions, where the corresponding findings were reported rationally. These interesting research findings provide useful tools for understanding the relationships between surfactants and drugs which are crucial for creating effective drugs formulations as well as improving surfactant and drug systems.
研究不同添加剂对药物 - 表面活性剂混合物聚集行为的影响对于改进药物制剂非常重要。本研究揭示了十二烷基硫酸钠（NaDS）与氧氟沙星（OFC）在不同pH值以及在298.15至323.15 K温度下不同电解质（KCl、KNO₃、KHSO₄和K₂SO₄）介质存在时的胶束化特性。使用电导法评估了NaDS和OFC体系的临界胶束浓度（CMC）、电离程度（α）和反离子结合程度（β）。发现CMC值随着盐含量的增加而下降，这表明在所使用的盐存在下有利于胶束化。在所有电解质溶液中，随着实验温度的升高，CMC值都会增加。NaDS + OFC体系在基于K的水性电解质介质中的吉布斯自由能[公式：见原文]值为负，表明该体系存在自发缔合。焓变（[公式：见原文]）和熵变（[公式：见原文]）表明，疏水相互作用和静电相互作用是水性电解质介质中各组分之间的相互作用力。还计算了转移热力学性质（[公式：见原文]、[公式：见原文]、[公式：见原文]）、摩尔热容[公式：见原文]补偿温度（T）以及固有焓增益（[公式：见原文]），并据此对结果进行了讨论。此外，使用紫外 - 可见光谱技术测定了NaDS和OFC在水溶液和含盐水溶液中的各种重要参数，包括结合常数（K）、分配常数（K）、分配系数（K）、结合吉布斯自由能（ΔG）和分配吉布斯自由能（ΔG），并合理报告了相应的研究结果。这些有趣的研究结果为理解表面活性剂与药物之间的关系提供了有用的工具，这对于开发有效的药物制剂以及改进表面活性剂和药物体系至关重要。
