癌症研究史：癌细胞的生长与代谢
A History of Cancer Research: Cancer Cell Growth and Metabolism.
作者信息
Lipsick Joseph
机构信息
Departments of Pathology, Genetics, and Biology, Stanford University, Stanford, California 94305-5324, USA
出版信息
Cold Spring Harb Perspect Med. 2025 Sep 2;15(9):a035782. doi: 10.1101/cshperspect.a035782.
Dysregulation of cell growth and metabolic changes are a feature of tumorigenesis. Studies over the past 50 years have mapped the pathways that control cell growth and metabolism and revealed how these are altered in cancer. In this excerpt from his forthcoming book on the history of cancer research, Joe Lipsick looks at how we got here-from early work on insulin and growth factor receptor signaling to the discovery of phosphatidyl inositol 3-kinase (PI 3-kinase), the identification of mTOR as the target of rapamycin, and the unexpected finding that tumors can produce novel "oncometabolites."
细胞生长失调和代谢变化是肿瘤发生的一个特征。过去50年的研究已经绘制出了控制细胞生长和代谢的信号通路，并揭示了这些通路在癌症中是如何改变的。在乔·利普西克即将出版的关于癌症研究历史的书中的这段摘录中，他探讨了我们是如何走到这一步的——从早期关于胰岛素和生长因子受体信号传导的研究，到磷脂酰肌醇3激酶（PI 3激酶）的发现，mTOR作为雷帕霉素靶点的鉴定，以及肿瘤能够产生新型“肿瘤代谢物”这一意外发现。
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