Ma Yilei, Jin Mengying, Zhen Yonghuan, An Yang
Department of Plastic Surgery, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing, 100191, China.
Aesthetic Plast Surg. 2025 Sep 2. doi: 10.1007/s00266-025-05194-z.
The increased demand for non-surgical rhinoplasty using hyaluronic acid (HA) has given impetus to explore more injection techniques and has also placed a higher demand on the coping of complications.
The purpose of this systematic review is to provide clinicians with recommendations by broadly consolidating data on HA injections for rhinoplasty injection techniques and complications, and presenting the advantages and disadvantages of each technique and the treatment of complications.
A systematic electronic literature search using keywords and MESH search terms over the PubMed/Medline, Cochrane Central, Embase, Web of Science, and CNKI online databases was conducted from 2000 to 2024. Risk of bias assessment was performed for all included articles.
There were 37 papers with a total of 7339 patients included in the study. Four different injection regimens were summarized. The incidence of serious complications such as blindness, skin necrosis, and cerebral infarction was only 3‰. Mild complications including bruising, hematoma, edema, and asymmetry had a higher incidence of 13.34%.
Existing techniques for hyaluronic acid nasal injections can be summarized as top-to-bottom approach, bottom-up approach, critical site injections, and multi-plane injections, with the latter two more innovative injections reporting higher complication rates in comparison.
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
对使用透明质酸（HA）进行非手术隆鼻的需求增加，推动了对更多注射技术的探索，也对并发症的处理提出了更高要求。
本系统评价的目的是通过广泛整合关于HA注射用于隆鼻的注射技术和并发症的数据，为临床医生提供建议，并介绍每种技术的优缺点以及并发症的治疗方法。
使用关键词和医学主题词（MESH）检索词，在2000年至2024年期间对PubMed/Medline、Cochrane Central、Embase、Web of Science和中国知网在线数据库进行系统的电子文献检索。对所有纳入的文章进行偏倚风险评估。
该研究纳入了37篇论文，共7339例患者。总结了四种不同的注射方案。失明、皮肤坏死和脑梗死等严重并发症的发生率仅为3‰。包括瘀伤、血肿、水肿和不对称在内的轻度并发症发生率较高，为13.34%。
现有的透明质酸鼻注射技术可概括为自上而下法、自下而上法、关键部位注射法和多平面注射法，后两种更具创新性的注射方法相比并发症发生率更高。
证据水平I：本刊要求作者为每篇文章指定证据水平。有关这些循证医学评级的完整描述，请参阅目录或作者在线指南 www.springer.com/00266。
