Mindfulness-Oriented Recovery Enhancement Reduces Illicit Substance Craving Among People with Alcohol Use Disorder and Polysubstance Use.

: Polysubstance use is common in alcohol use disorder (AUD) and associated with poor treatment outcomes. Cannabis and cocaine often co-used with alcohol, have no approved medication treatments and respond poorly to common behavioral treatments. Thus, treatments that can reduce use of these substances alongside AUD are critically needed. : We tested whether Mindfulness-Oriented Recovery Enhancement (MORE), an evidence-based group therapy approach combining mindfulness, cognitive-behavioral techniques, and savoring natural rewards could simultaneously reduce cravings for cannabis and/or cocaine. Given MORE's demonstrated efficacy for treating other addictive behaviors, we hypothesized it would reduce craving for cannabis and/or cocaine in people with AUD. : Participants ( = 50) were adults with AUD who also used cocaine and/or cannabis. Participants were randomly assigned to ten-sessions of either MORE or supportive group (SG) psychotherapy control condition, both targeting at AUD. Illicit substance craving was assessed before and after treatment during a cue reactivity protocol consisting of a resting baseline, 5-min stress imagery exposure, 5-min alcohol image exposure, and 5-min recovery period. : Results revealed a significant Group-X Time interaction, = 7.06, =.008, indicating that patients randomized to MORE reported significantly greater reductions in illicit substance craving across the entire cue-reactivity protocol from pre- to post-treatment. However, the Group-X Time-X Condition interaction was nonsignificant (=.61), indicating that the effect of MORE did not significantly vary by condition. : Results from this pilot study suggest that MORE may reduce illicit substance craving in patients with polysubstance use and AUD. MORE should be further evaluated in full-scale randomized clinical trials for cannabis and cocaine use disorder.