van den Dries Carline J, Dongelmans Dave A, van der Laan Maarten J, Oomkens Sonja, Ouwendijk Eva, Visser Annelies, Rutten Frans H, Zwart Dorien L M
Department of General Practice & Nursing Science, Julius Center for Health Sciences and Primary care, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, Utrecht, 3508 AB, The Netherlands.
Department of Intensive Care Medicine, Amsterdam UMC, Amsterdam Public Health, University of Amsterdam, Amsterdam, Netherlands.
Int J Emerg Med. 2025 Sep 2;18(1):163. doi: 10.1186/s12245-025-00974-5.
Ruptured abdominal aortic aneurysm (rAAA) is rare but it is the second most frequently missed diagnosis reported as sentinel adverse event ('calamity') at out-of-hours services in primary care (OHS-PC). We aimed to identify characteristics that could be useful for telephone triage of suspected rAAA at the OHS-PC.
In a matched case-control study (1:4 ratio), we compared patients with a missed rAAA (cases) to patients with the same age and sex, and with similar entrance complaint (controls). Data were collected from OHS-PC triage call recordings that were re-assessed by researchers blinded to the case-control status. Patient and call characteristics were univariably assessed with conditional logistic regression analysis.
Twenty cases of missed rAAA between 2013 and 2023 were matched to 80 controls. 40% of the cases presented with abdominal pain, and 35% with back pain. Cases compared to controls more often had a pain onset < 12 h (odds ratio (OR) 15.2; 95%CI 1.9-123.8), reported more sweating (OR 10.1; 95% CI 1.2-86.9, p = 0.035), more often verbally expressed their concern (OR 13.6; 95%CI 3.0-61.3, p = 0.001), and more often called during the night (OR 3.8; 95% CI 1.1-12.7, p = 0.029).
Recognition of rAAA at the OHS-PC remains challenging given its rare occurrence and lack of specific symptoms. Nevertheless, this case-control study identified factors that could be useful in triage of patients calling the OHS-PC with symptoms possibly indicating rAAA.
腹主动脉瘤破裂(rAAA)较为罕见,但在基层医疗非工作时间服务(OHS-PC)中,它是作为哨兵不良事件(“灾难”)报告的第二常见漏诊疾病。我们旨在确定有助于OHS-PC对疑似rAAA进行电话分诊的特征。
在一项匹配病例对照研究(1:4比例)中,我们将漏诊rAAA的患者(病例)与年龄、性别相同且入院主诉相似的患者(对照)进行比较。数据收集自OHS-PC分诊呼叫记录,由对病例对照状态不知情的研究人员重新评估。通过条件逻辑回归分析对患者和呼叫特征进行单变量评估。
2013年至2023年间的20例漏诊rAAA病例与80例对照匹配。40%的病例表现为腹痛,35%表现为背痛。与对照组相比,病例组疼痛发作时间<12小时的情况更常见(比值比(OR)15.2;95%置信区间1.9 - 123.8),出汗更多(OR 10.1;95%置信区间1.2 - 86.9,p = 0.035),更常口头表达担忧(OR 13.6;95%置信区间3.0 - 61.3,p = 0.001),夜间呼叫的情况也更常见(OR 3.8;95%置信区间1.1 - 12.7,p = 0.029)。
鉴于rAAA罕见且缺乏特异性症状,在OHS-PC中识别rAAA仍然具有挑战性。尽管如此,这项病例对照研究确定了一些因素,这些因素可能有助于对因可能提示rAAA症状而致电OHS-PC的患者进行分诊。