O'Brien J R, Etherington M D, Pashley M A
Thromb Haemost. 1985 Dec 17;54(4):735-8.
Some clinical advantages are claimed for low molecular weight heparin so the mobilisation of platelet factor 4 (PF 4) from the endothelial pool by the heparins may be relevant. Unfractionated (UF) heparin has been compared with Kabi heparin fragment 2165. A single intravenous (i.v.) injection of 60 iu/kg heparin was compared with 5000 anti-Xa units of Kabi-2165. Less PF 4 was mobilised by Kabi-2165 and some apparently remained in the pool and was released when the pool was subsequently challenged by giving i.v. heparin. Subcutaneous (s.c.) injections of 5000 iu heparin twice daily were compared with 5000 anti-Xa units of Kabi-2165 once daily, each given for a week. The plasma PF 4 was never raised yet when finally challenged with i.v. heparin the pool was "empty" or refractory after the s.c. heparin but some PF 4 remained after the s.c. Kabi-2165. The two glycosaminoglycans (GAGs) had widely differing half-lives but the t/2 of the PF 4 mobilised by the two GAGs was similar even though the PF 4 is apparently bound to the GAG.
低分子量肝素具有一些临床优势，因此肝素从内皮细胞池动员血小板因子4（PF 4）可能与之相关。已将普通肝素（UF）与卡比肝素片段2165进行了比较。将60 iu/kg肝素的单次静脉注射与5000抗Xa单位的卡比-2165进行比较。卡比-2165动员的PF 4较少，一些显然仍留在池中，当随后通过静脉注射肝素刺激该池时会被释放。将每日两次皮下注射5000 iu肝素与每日一次皮下注射5000抗Xa单位的卡比-2165进行比较，每种给药一周。皮下注射肝素后血浆PF 4从未升高，但最终用静脉注射肝素刺激时，皮下注射肝素后该池“空了”或不应答，而皮下注射卡比-2165后仍有一些PF 4残留。这两种糖胺聚糖（GAGs）的半衰期差异很大，但两种GAGs动员的PF 4的t/2相似，尽管PF 4显然与GAG结合。
