中国老年人的肌肉减少症、睡眠时间与成功老龄化的可能性：一项前瞻性队列研究。

Sarcopenia and sleep duration with the likelihood of successful aging among older adults in China: a prospective cohort study.

作者信息

Liang Bo, Hou Dingchun, Li Jiajia, Chen Gong, Pei Lijun

机构信息

Institute of Population Research, Peking University, Beijing, China.

出版信息

BMC Geriatr. 2025 Sep 2;25(1):679. doi: 10.1186/s12877-025-06360-3.

DOI:10.1186/s12877-025-06360-3

PMID:40898087

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12406554/

Abstract

BACKGROUND

Sarcopenia and sleep duration have emerged as crucial health-related factors in geriatric research. This study aimed to investigate the independent and joint associations of sarcopenia and sleep duration with successful aging and its components among older adults in China.

METHODS

A dynamic 10-year cohort of 6,410 adults aged ≥ 60 was constructed using the China Health and Retirement Longitudinal Study (CHARLS) data (2011-2020). Sarcopenia was identified using the Asian Working Group for Sarcopenia (AWGS) 2019 criteria. Sleep duration encompassed nighttime sleep and naps. Cox proportional hazards regression and multivariable logistic regression were used to examine the associations. Sensitivity analyses were conducted using alternative definitions of successful aging and applying generalized linear mixed models.

RESULTS

The mean age of the participants at baseline was 67.05 ± 6.30 years. Compared to non-sarcopenia adults, those with possible sarcopenia and sarcopenia had a 39% (HR = 0.61, 95%CI: 0.52-0.71) and 45% (HR = 0.55, 95%CI: 0.45-0.67) lower likelihood of successful aging, respectively, with a significant dose-response relationship (P < 0.001). Sleep durations of 6-8 h, 8-9 h and ≥ 9 h increased the likelihood of successful aging by 49% (HR = 1.49, 95% CI: 1.25-1.77), 46% (HR = 1.46, 95% CI: 1.19-1.78) and 48% (HR = 1.48, 95% CI: 1.21-1.91), respectively, compared to < 6 h sleep. Joint analysis revealed that individuals with sarcopenia and short sleep (< 6 h) had the lowest probability of successful aging (HR = 0.38, 95% CI: 0.28-0.52), suggesting a cumulative detrimental effect. Both possible sarcopenia and sarcopenia was associated with decreased likelihood of no major disease, no disability, high cognitive function, and no depressive symptoms in the successful aging. Subgroup analyses showed consistent effects of sarcopenia across demographic groups. Sensitivity analyses confirmed the robustness and reliability of the primary findings.

CONCLUSIONS

Sarcopenia and short sleep duration independently and jointly hinder successful aging. Community sarcopenia screening integrated into primary care and advocating adequate sleep duration may served as a cost-effective successful aging strategy.

摘要

背景

肌肉减少症和睡眠时间已成为老年医学研究中与健康相关的关键因素。本研究旨在调查中国老年人中肌肉减少症和睡眠时间与成功老龄化及其组成部分之间的独立关联和联合关联。

方法

利用中国健康与养老追踪调查（CHARLS）数据（2011 - 2020年）构建了一个动态的10年队列，其中包括6410名年龄≥60岁的成年人。采用亚洲肌肉减少症工作组（AWGS）2019年标准来识别肌肉减少症。睡眠时间包括夜间睡眠和午睡。使用Cox比例风险回归和多变量逻辑回归来检验这些关联。采用成功老龄化的替代定义并应用广义线性混合模型进行敏感性分析。

结果

参与者在基线时的平均年龄为67.05±6.30岁。与非肌肉减少症成年人相比，可能患有肌肉减少症和肌肉减少症的成年人成功老龄化的可能性分别降低了39%（HR = 0.61，95%CI：0.52 - 0.71）和45%（HR = 0.55，95%CI：0.45 - 0.67），存在显著的剂量反应关系（P < 0.001）。与睡眠时间<6小时相比，睡眠时间为6 - 8小时、8 - 9小时和≥9小时的成功老龄化可能性分别增加了49%（HR = 1.49，95%CI：1.25 - 1.77）、46%（HR = 1.46，95%CI：1.19 - 1.78）和48%（HR = 1.48，95%CI：1.21 - 1.91）。联合分析显示，患有肌肉减少症且睡眠短（<6小时）的个体成功老龄化的概率最低（HR = 0.38，95%CI：0.28 - 0.52），表明存在累积有害效应。在成功老龄化方面，可能患有肌肉减少症和肌肉减少症均与无重大疾病、无残疾、高认知功能和无抑郁症状的可能性降低有关。亚组分析显示，肌肉减少症在各人口统计学组中的影响一致。敏感性分析证实了主要发现的稳健性和可靠性。