Yu Yilin, Feng Yiyi, Han Yanping, Yang Jie, Wen Xuyang, Fan Xianqun, Fan Jiayan
Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, P.R. China.
BMC Psychiatry. 2025 Sep 2;25(1):850. doi: 10.1186/s12888-025-07229-w.
Recent studies indicate parents of childhood cancer survivors experience high psychological burden. However, there is limited knowledge regarding the mental health of parents of children with retinoblastoma (RB) in China. Thus, the purpose of this study was to assess anxiety, depression, fear of disease progression (FoP), and family function among parents of children with RB, and to analyze associated factors.
This cross-sectional study enrolled 151 RB patients and 185 of their parents. Parents completed the Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Fear of Progression Questionnaire-Short Form/Parent version (FoP-Q-SF/PR), and Family APGAR Index to assess the levels of anxiety, depression, FoP, family function. Univariate and multivariate analyses were performed to identify associated factors.
Clinically relevant anxiety and depression were reported in 34% and 41% of parents of children with RB. FoP-related dysfunction was observed in 68.1% of parents. More than half of the families (54.9%) exhibited family dysfunction. Anxiety level demonstrated positive correlations with urban residency and BDI scores. The increase in the number of intravenous chemotherapy (IVC), tumor recurrence, urban residency and BAI scores were associated with parental depression levels. Additionally, multivariate analysis included IVC, religious belief, ethnic minority groups and BDI scores as independent risk factors for FoP.
Anxiety, depression and FoP represented substantial burdens for parents of children with RB, which were relate to IVC, age at diagnosis, tumor recurrence, place of residence, and education level of parents. Consequently, during treatment of RB, particular attention needs to be paid to the psychological health of parents, psychological interventions should be provided when necessary.
近期研究表明，儿童癌症幸存者的父母承受着较高的心理负担。然而，在中国，关于视网膜母细胞瘤（RB）患儿父母心理健康的了解有限。因此，本研究旨在评估RB患儿父母的焦虑、抑郁、疾病进展恐惧（FoP）和家庭功能，并分析相关因素。
本横断面研究纳入了151例RB患者及其185名父母。父母完成了贝克焦虑量表（BAI）、贝克抑郁量表（BDI）、疾病进展恐惧问卷简版/父母版（FoP-Q-SF/PR）和家庭APGAR指数，以评估焦虑、抑郁、FoP和家庭功能水平。进行单因素和多因素分析以确定相关因素。
RB患儿父母中，分别有34%和41%报告有临床相关的焦虑和抑郁。68.1%的父母存在与FoP相关的功能障碍。超过一半的家庭（54.9%）表现出家庭功能障碍。焦虑水平与城市居住情况和BDI得分呈正相关。静脉化疗（IVC）次数增加、肿瘤复发、城市居住情况和BAI得分与父母抑郁水平相关。此外，多因素分析将IVC、宗教信仰、少数民族群体和BDI得分作为FoP的独立危险因素。
焦虑、抑郁和FoP给RB患儿父母带来了沉重负担，这些负担与IVC、诊断年龄、肿瘤复发、居住地和父母教育水平有关。因此，在RB治疗期间，需要特别关注父母的心理健康，必要时应提供心理干预。
