Qu Xinrong, Li Chen, Zhang Chun
Department of Breast Surgery, Peking University International Hospital, Beijing, China.
Medicine (Baltimore). 2025 Aug 29;104(35):e44108. doi: 10.1097/MD.0000000000044108.
Liposarcoma, the most common type of soft tissue sarcoma, typically occurs in the deep soft tissues of the limbs and retroperitoneum and is rarely found in the breast. The fifth edition of the World Health Organization classifies it into 5 distinct histological subtypes. Given the rarity of liposarcomas in breast tissue, there remain certain challenges in diagnosis and treatment planning. In this report, we present a rare case of an atypical lipomatous tumor/well-differentiated liposarcoma in breast tissue.
A 65-year-old female patient with an asymptomatic movable mass in the left breast was admitted to our hospital. The mass persisted for approximately half a month. Clinical examination and ultrasound examination revealed that the mass within the fatty layer of the left breast was approximately 7.0 cm × 7.0 cm and relatively well circumscribed.
The preoperative tests led to a preliminary diagnosis of lipoma; therefore, the patient underwent mass resection of the left breast under local anesthesia. Postoperative pathological analysis indicated a diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma.
Considering the lower malignancy of this pathological type, we performed radical surgical excision and followed the patient for 3 months after surgery.
No significant signs of recurrence or metastasis were detected during the time.
Liposarcoma is rarely found in breast tissue. Moreover, it is difficult to distinguish between lipomas and liposarcomas by assistant examination. In this case report, we sought to enhance the awareness and understanding of breast liposarcoma. Understanding the clinical and pathological characteristics of this rare disease will aid clinicians in better recognition and diagnosis in future clinical practice, as well as in exploring more comprehensive and precise treatment plans and prognosis evaluation systems.
脂肪肉瘤是软组织肉瘤最常见的类型，通常发生于四肢深部软组织和腹膜后，很少见于乳腺。世界卫生组织第五版将其分为5种不同的组织学亚型。鉴于乳腺组织中脂肪肉瘤罕见，在诊断和治疗规划方面仍存在一定挑战。在本报告中，我们呈现了1例乳腺组织中罕见的非典型脂肪瘤样肿瘤/高分化脂肪肉瘤病例。
一名65岁女性患者因左乳有无症状可移动肿块入院。肿块持续约半个月。临床检查和超声检查显示左乳脂肪层内肿块约7.0 cm×7.0 cm，边界相对清晰。
术前检查初步诊断为脂肪瘤；因此，患者在局部麻醉下行左乳肿块切除术。术后病理分析表明诊断为非典型脂肪瘤样肿瘤/高分化脂肪肉瘤。
考虑到该病理类型恶性程度较低，我们进行了根治性手术切除，并在术后对患者进行了3个月的随访。
在此期间未检测到复发或转移的明显迹象。
脂肪肉瘤在乳腺组织中罕见。此外，通过辅助检查难以区分脂肪瘤和脂肪肉瘤。在本病例报告中，我们旨在提高对乳腺脂肪肉瘤的认识和理解。了解这种罕见疾病的临床和病理特征将有助于临床医生在未来临床实践中更好地识别和诊断，以及探索更全面、精确的治疗方案和预后评估系统。
