Muqeet Abdul, Sajid Emad Uddin, Ibrahim Mohammad Faisal, Atif Anfal, Hyder Absar, Siraj Muhammad Imran, Fakih Nour
Department of Surgery, Dow University of Health Sciences, Karachi, Pakistan.
Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Medicine (Baltimore). 2025 Jul 25;104(30):e43528. doi: 10.1097/MD.0000000000043528.
Retroperitoneal liposarcomas are rare mesenchymal tumors often diagnosed late due to asymptomatic growth. While they typically extend into adjacent retroperitoneal structures, invasion into the thigh is exceedingly rare, posing unique diagnostic and therapeutic challenges.
A 45-year-old South Asian female presented with a progressively enlarging swelling in the left upper thigh, extending into the left inguinal and flank regions, accompanied by intermittent pain.
Imaging revealed a large, lobulated, fat-attenuating mass measuring 11 × 9 cm in the axial plane with a craniocaudal extent of 30.7 cm, spanning from the retroperitoneum to the thigh. Histopathology confirmed a well-differentiated liposarcoma.
The patient underwent surgical resection via a combined laparotomy and thigh incision, achieving complete excision with negative margins.
Postoperative recovery was uneventful. At 6-month follow-up, there was no tumor recurrence or functional limitation reported.
This case highlights the importance of comprehensive imaging and meticulous surgical planning in managing atypical tumor extensions such as retroperitoneal liposarcomas invasion into the thigh. Given the rarity of this presentation, it contributes valuable insights into clinical and surgical management strategies for similar cases.
腹膜后脂肪肉瘤是一种罕见的间叶组织肿瘤，因其生长无症状，常在晚期才被诊断出来。虽然它们通常会侵犯相邻的腹膜后结构，但侵犯至大腿极为罕见，这带来了独特的诊断和治疗挑战。
一名45岁的南亚女性，左大腿上部出现逐渐增大的肿块，延伸至左腹股沟和侧腹区域，并伴有间歇性疼痛。
影像学检查显示，在轴位平面上有一个11×9厘米的大的、分叶状、脂肪衰减肿块，头尾径为30.7厘米，从腹膜后延伸至大腿。组织病理学证实为高分化脂肪肉瘤。
患者通过剖腹术和大腿切口联合进行手术切除，实现了切缘阴性的完整切除。
术后恢复顺利。在6个月的随访中，未报告肿瘤复发或功能受限情况。
该病例强调了在处理非典型肿瘤扩展（如腹膜后脂肪肉瘤侵犯至大腿）时，全面成像和精心手术规划的重要性。鉴于这种表现的罕见性，它为类似病例的临床和手术管理策略提供了宝贵的见解。
