Hu Wentao, Jiang Yifang, Wang Jie, Jia Min, Wu Chunlan, Wen Changhui
Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Department of Endocrinology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Medicine (Baltimore). 2025 Aug 29;104(35):e44173. doi: 10.1097/MD.0000000000044173.
Psoriasis is a chronic autoimmune disease marked by excessive keratinocyte growth and immune issues. Xiao Bi decoction (XBT), a traditional Chinese formula, has shown effective for treating psoriasis. This study integrated network pharmacology and Mendelian randomization analysis to explore the therapeutic mechanism of XBT and validate causal relationships between its active components, potential targets, and psoriasis outcomes. The results showed that XBT contains 171 active components, of which the top 5 active components with the highest degree values were quercetin, dihydrobaicalin _qt, Pyrethrin II, Kinobeon A, and Baicalein; the main core targets of XBT were tumor necrosis factor, interleukin (IL)-6, glyceraldehyde-3-phosphate dehydrogenase, AKT1, and IL-1B. These core components and core targets can be better molecular docking, and Mendelian randomization analysis showed that there is a causal relationship between the reduced level of IL-6 and the increased risk of psoriasis. These results provide novel insights into the molecular mechanisms and scientific validation of XBT's use in psoriasis.
银屑病是一种慢性自身免疫性疾病，其特征为角质形成细胞过度生长和免疫问题。中药方剂消痹汤（XBT）已显示出对银屑病的治疗效果。本研究结合网络药理学和孟德尔随机化分析，以探索消痹汤的治疗机制，并验证其活性成分、潜在靶点与银屑病结局之间的因果关系。结果显示，消痹汤含有171种活性成分，其中度值最高的前5种活性成分是槲皮素、二氢黄芩苷_qt、除虫菊酯II、奇诺贝酮A和黄芩素；消痹汤的主要核心靶点是肿瘤坏死因子、白细胞介素（IL）-6、甘油醛-3-磷酸脱氢酶、AKT1和IL-1B。这些核心成分和核心靶点能够进行更好的分子对接，孟德尔随机化分析表明IL-6水平降低与银屑病风险增加之间存在因果关系。这些结果为消痹汤治疗银屑病的分子机制和科学验证提供了新的见解。
