College of Pharmaceutical Sciences, The Second Affiliated Hospital, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China.
National Key Laboratory of Diagnosis and Treatment of Severe Infectious Disease, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang 310000, China.
Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751.
Target discovery is one of the essential steps in modern drug development, and the identification of promising targets is fundamental for developing first-in-class drug. A variety of methods have emerged for target assessment based on druggability analysis, which refers to the likelihood of a target being effectively modulated by drug-like agents. In the therapeutic target database (TTD), nine categories of established druggability characteristics were thus collected for 426 successful, 1014 clinical trial, 212 preclinical/patented, and 1479 literature-reported targets via systematic review. These characteristic categories were classified into three distinct perspectives: molecular interaction/regulation, human system profile and cell-based expression variation. With the rapid progression of technology and concerted effort in drug discovery, TTD and other databases were highly expected to facilitate the explorations of druggability characteristics for the discovery and validation of innovative drug target. TTD is now freely accessible at: https://idrblab.org/ttd/.
靶点发现是现代药物开发的重要步骤之一，而有前途的靶点的鉴定对于开发首创药物至关重要。基于可成药性分析的靶点评估方法层出不穷，可成药性是指靶点被类药性药物有效调控的可能性。在治疗靶点数据库（TTD）中，通过系统评价收集了 426 个成功靶点、1014 个临床试验靶点、212 个临床前/专利靶点和 1479 个文献报道靶点的 9 类已建立的可成药性特征。这些特征类别分为三个不同的视角：分子相互作用/调节、人体系统概况和基于细胞的表达变化。随着技术的快速发展和药物发现的协同努力，TTD 和其他数据库有望促进可成药性特征的探索，从而发现和验证创新药物靶点。TTD 现在可在以下网址免费获取：https://idrblab.org/ttd/。
Zotero 插件
