Perfect Chelsea R, Bowling C Barrett, Lim S Sam, Dunlop-Thomas Charmayne, Hoge Courtney, Yazdany Jinoos, Katz Patricia P, Plantinga Laura C
Duke University School of Medicine and Durham Veterans Affairs Geriatric Research Education and Clinical Center, Durham VA Medical Center, Durham, North Carolina.
Emory University, Atlanta, Georgia.
ACR Open Rheumatol. 2025 Sep;7(9):e70098. doi: 10.1002/acr2.70098.
Systemic lupus erythematosus (SLE) is thought to accelerate the aging process. However, there is limited research on geriatric syndromes, such as falls, in this potentially vulnerable population. This study aimed to describe the prevalence of and contributors to falls in the SLE population.
Participants were recruited from an ongoing population-based cohort of individuals with validated SLE. Falls (number of falls and fall-related injuries requiring medical attention over the past year) and perceived contributing factors were self-reported. Descriptive statistics were calculated, and age-, sex-, and race-adjusted odds ratios (aORs) of participant characteristics with falls were estimated using multivariable logistic regression.
Nearly one-third (30.7%) of participants (overall N = 447; 40.9% aged ≥50 years, 91.7% female, and 82.6% Black) reported falling in the past year; 19.2% fell twice or more. Loss of balance (78.1% of falls), slipping/tripping (64.2%), and weakness (53.3%) were the most commonly reported contributing factors. Age and sex were not associated with falls, but higher physical performance (aOR, 0.78; 95% confidence interval [CI], 0.71-0.87) was associated with lower odds of falls. Higher SLE activity (aOR, 1.78; 95% CI, 1.44-2.21) and damage (aOR, 1.22; 95% CI, 1.00-1.49), greater depressive symptoms (aOR, 1.43; 95% CI, 1.14,1-80), and taking fall risk-increasing drugs (antidepressants: aOR, 1.82; 95% CI, 1.13-2.93; pain medications: aOR, 2.60; 95% CI, 1.68-4.00; opioids: aOR, 4.52; 95% CI, 2.39-8.56) were associated with higher odds of falls.
Falls were common in our cohort, regardless of age. Our results suggest potential interventions for reducing falls, like better control of SLE, physical therapy, depression screening, and medication review.
系统性红斑狼疮（SLE）被认为会加速衰老过程。然而，针对这一潜在脆弱人群的老年综合征，如跌倒，的研究有限。本研究旨在描述SLE人群中跌倒的患病率及其影响因素。
参与者来自一个正在进行的基于人群的经确诊的SLE队列。跌倒情况（过去一年的跌倒次数以及需要医疗关注的与跌倒相关的损伤）和感知到的影响因素通过自我报告获得。计算描述性统计数据，并使用多变量逻辑回归估计参与者特征与跌倒相关的年龄、性别和种族调整后的优势比（aOR）。
近三分之一（30.7%）的参与者（总体N = 447；40.9%年龄≥50岁，91.7%为女性，82.6%为黑人）报告在过去一年中跌倒过；19.2%的人跌倒过两次或更多次。平衡丧失（跌倒原因的78.1%）、滑倒/绊倒（64.2%）和虚弱（53.3%）是最常报告的影响因素。年龄和性别与跌倒无关，但身体机能较好（aOR，0.78；95%置信区间[CI]，0.71 - 0.87）与跌倒几率较低相关。较高的SLE活动度（aOR，1.78；95% CI，1.44 - 2.21）和损伤（aOR，1.22；95% CI，1.00 - 1.49）、更严重的抑郁症状（aOR，1.43；95% CI，1.14 - 1.80）以及服用增加跌倒风险的药物（抗抑郁药：aOR，
