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PCDHGB7 inhibits the progression of triple-negative breast cancer by suppressing XRCC5/MYC-mediated ribosome biogenesis.

作者信息

Shan Ming, Bi Hongjie, Sun Hua, Li Yixin, Li Zhiqi, Wang Ziyuan, Dong Jianguo, Sang Shengbo, Ren Lili, Ye Yuguang, Wang Tianzhen, Volarević Siniša, Su Rui, Zhang Lei, Zhang Minghui, He Yan, Zhang Guoqiang, Li Jing, Li Xiaobo

机构信息

Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.

Department of Pathology, School of Basic Medical Science, Harbin Medical University, Harbin, China.

出版信息

Clin Transl Med. 2025 Sep;15(9):e70437. doi: 10.1002/ctm2.70437.

DOI:10.1002/ctm2.70437
PMID:40898765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12405659/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a180/12405659/f084643b9b1d/CTM2-15-e70437-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a180/12405659/aea7c1df682d/CTM2-15-e70437-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a180/12405659/da208dc51084/CTM2-15-e70437-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a180/12405659/6eef135e4427/CTM2-15-e70437-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a180/12405659/f084643b9b1d/CTM2-15-e70437-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a180/12405659/aea7c1df682d/CTM2-15-e70437-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a180/12405659/da208dc51084/CTM2-15-e70437-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a180/12405659/6eef135e4427/CTM2-15-e70437-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a180/12405659/f084643b9b1d/CTM2-15-e70437-g003.jpg

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PCDHGB7 inhibits the progression of triple-negative breast cancer by suppressing XRCC5/MYC-mediated ribosome biogenesis.PCDHGB7通过抑制XRCC5/ MYC介导的核糖体生物合成来抑制三阴性乳腺癌的进展。
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本文引用的文献

1
The IGF2BP3-COPS7B Axis Facilitates mRNA Translation to Drive Colorectal Cancer Progression.IGF2BP3-COPS7B 轴促进 mRNA 翻译以推动结直肠癌进展。
Cancer Res. 2023 Nov 1;83(21):3593-3610. doi: 10.1158/0008-5472.CAN-23-0557.
2
Targeting the radiation-induced ARv7-mediated circNHS/miR-512-5p/XRCC5 signaling with Quercetin increases prostate cancer radiosensitivity.槲皮素通过靶向辐射诱导的 ARv7 介导的 circNHS/miR-512-5p/XRCC5 信号通路增加前列腺癌的放射敏感性。
J Exp Clin Cancer Res. 2022 Aug 3;41(1):235. doi: 10.1186/s13046-022-02287-4.
3
Myc as a Regulator of Ribosome Biogenesis and Cell Competition: A Link to Cancer.
Myc 作为核糖体生物发生和细胞竞争的调节剂：与癌症的联系。
Int J Mol Sci. 2020 Jun 5;21(11):4037. doi: 10.3390/ijms21114037.
4
Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis.核糖体蛋白表达和翻译的失调促进乳腺癌转移。
Science. 2020 Mar 27;367(6485):1468-1473. doi: 10.1126/science.aay0939. Epub 2020 Feb 6.
5
High expression of XRCC5 is associated with metastasis through Wnt signaling pathway and predicts poor prognosis in patients with hepatocellular carcinoma.XRCC5 的高表达通过 Wnt 信号通路与转移相关，并预测肝癌患者的预后不良。
Eur Rev Med Pharmacol Sci. 2019 Sep;23(18):7835-7847. doi: 10.26355/eurrev_201909_18993.
6
Ribosome biogenesis in cancer: new players and therapeutic avenues.癌症中的核糖体生物发生：新的参与者和治疗途径。
Nat Rev Cancer. 2018 Jan;18(1):51-63. doi: 10.1038/nrc.2017.104. Epub 2017 Dec 1.
7
XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers.XRCC5与p300协同作用，促进结肠癌中环氧合酶-2的表达及肿瘤生长。
PLoS One. 2017 Oct 19;12(10):e0186900. doi: 10.1371/journal.pone.0186900. eCollection 2017.
8
The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer.靶向核糖体生物合成在高级别浆液性卵巢癌中的潜力
Int J Mol Sci. 2017 Jan 20;18(1):210. doi: 10.3390/ijms18010210.
9
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency.核糖体蛋白单倍剂量不足对Myc致癌活性的抑制作用。
Nature. 2008 Dec 18;456(7224):971-5. doi: 10.1038/nature07449. Epub 2008 Nov 16.
10
Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer.核糖体生物合成及癌症过程中c-Myc与核糖体之间的相互作用
J Cell Biochem. 2008 Oct 15;105(3):670-7. doi: 10.1002/jcb.21895.