溴二氯甲烷对大鼠肝微粒体脂质代谢的急性影响。

Acute effect of bromodichloromethane on lipid metabolism in rat liver microsomes.

作者信息

Koyama Y, Nakazawa Y

出版信息

Toxicol Lett. 1985 Dec;29(2-3):123-30. doi: 10.1016/0378-4274(85)90032-3.

Abstract

Acute effects of CHBrCl2 on microsomal lipid metabolism were studied in the liver of male Wistar rats administered a single oral dose (215 mg/kg). 3 h after administration, the modulation of phospholipid metabolism and the accumulation of triacylglycerol (TG) were noted in the microsomal membranes. A marked decrease in the synthetic rate of phospatidylcholine (PC) could be explained by a fall in the microsomal activity of CTP:phosphocholine cytidylyltransferase. A decrease in glycerophosphate acyltransferase activity and an enhancement in phosphatidate phosphatase activity seemed to offset each other, and consequently no significant change was observed in the synthetic rate of microsomal TG. These alterations in microsomal lipid metabolism can be regarded as one of the manifestations of hepatotoxicity of CHBrCl2.

摘要

研究了在单次口服剂量（215mg/kg）的雄性Wistar大鼠肝脏中，二溴一氯甲烷（CHBrCl2）对微粒体脂质代谢的急性影响。给药3小时后，在微粒体膜中发现磷脂代谢的调节和三酰甘油（TG）的积累。磷脂酰胆碱（PC）合成速率的显著下降可以用CTP：磷酸胆碱胞苷转移酶的微粒体活性下降来解释。甘油磷酸酰基转移酶活性的降低和磷脂酸磷酸酶活性的增强似乎相互抵消，因此微粒体TG的合成速率没有观察到显著变化。微粒体脂质代谢的这些改变可被视为CHBrCl2肝毒性的表现之一。