Humber D C, Jones P S, Phillipps G H
Steroids. 1985 Jan;45(1):19-30. doi: 10.1016/0039-128x(85)90062-5.
The four diastereomeric 3,16-diacetates 6, 9, 10 and 11 were prepared from gitoxin 1 by the routes shown in Schemes 1 and 2 and tested for inotropic activity in the isolated guinea-pig atrial preparation. In line with earlier findings in the digitoxigenin series, derivatives with a 3 alpha-acetoxy function, viz 9 and 10, possessed high biological activity.
通过方案1和方案2所示的路线，由吉托辛1制备了四种非对映异构的3,16 - 二乙酸酯6、9、10和11，并在离体豚鼠心房制备物中测试了它们的变力活性。与洋地黄毒苷元系列的早期研究结果一致，具有3α - 乙酰氧基官能团的衍生物，即9和10，具有高生物活性。
