Mittler J C
Steroids. 1985 Feb;45(2):135-42. doi: 10.1016/0039-128x(85)90042-x.
Microsomal preparations from adult male rat testicular interstitial cells were incubated with tritiated testosterone. Added 7 alpha-hydroxytestosterone, (7 alpha,17 beta-dihydroxy-4-androsten-3-one), at levels which appear to exist in the adult testis, inhibited production of labelled 5 alpha-reduced steroids in a graded fashion. This interaction is not competitive and occurs only at high substrate levels, such as those found in steroid-producing organs. Relationships to pubertal changes in steroid metabolism are discussed.
将成年雄性大鼠睾丸间质细胞的微粒体制剂与氚标记的睾酮一起孵育。添加的7α-羟基睾酮（7α,17β-二羟基-4-雄烯-3-酮），其水平似乎与成年睾丸中存在的水平相同，以分级方式抑制标记的5α-还原类固醇的产生。这种相互作用不是竞争性的，并且仅在高底物水平下发生，例如在类固醇生成器官中发现的水平。讨论了其与青春期类固醇代谢变化的关系。
