Estañol B, Aguilar F, Corona T
Stroke. 1985 Nov-Dec;16(6):1006-9. doi: 10.1161/01.str.16.6.1006.
Naloxone was given as an I.V. bolus of 0.8 mgs to four groups of patients with stroke: 1) 20 patients with C.T. proven cerebral infarcts of longer than 7 days duration; 2) 20 patients with acute cerebral ischemia of less than 24 hours; 3) 5 patients with C.T. proven intracerebral hemorrhage of less than 24 hours, and; 4) 3 patients with hyperacute cerebral ischemia which occurred during the performance of a cerebral angiogram. The patients with established cerebral infarctions of more than 7 days duration and the patients with intracerebral hematomas had no response to intravenous naloxone. Of 20 patients with acute cerebral ischemia of less than 24 hours duration, 7 had prompt, complete and long-lasting recovery. These patients had no subsequent evidence of cerebral infarct by C.T. scanner 48 hours after the onset of the cerebral ischemia and were asymptomatic when discharged. The 3 patients with hyperacute cerebral ischemia secondary to cerebral angiography had a dramatic response to the injection of naloxone. These findings suggest that intravenous naloxone may differentiate reversible versus irreversible cerebral ischemia.
纳洛酮以0.8毫克静脉推注的方式给予四组中风患者：1）20例经CT证实脑梗死持续时间超过7天的患者；2）20例急性脑缺血时间少于24小时的患者；3）5例经CT证实脑出血时间少于24小时的患者；4）3例在脑血管造影过程中发生超急性脑缺血的患者。脑梗死持续时间超过7天的确诊患者和脑内血肿患者对静脉注射纳洛酮无反应。在20例急性脑缺血时间少于24小时的患者中，7例迅速、完全且持久地康复。这些患者在脑缺血发作48小时后经CT扫描无后续脑梗死证据，出院时无症状。3例因脑血管造影继发超急性脑缺血的患者对注射纳洛酮有显著反应。这些发现表明静脉注射纳洛酮可能区分可逆性与不可逆性脑缺血。
