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干眼症的诊断方法。

Diagnostic methods for managing dry eyes.

作者信息

Musa Mutali, Suleman Ayuba, Okechukwu Clinton, Bale Babatunde Ismail, Gagliano Caterina, D'Esposito Fabiana, Zeppieri Marco

机构信息

Department of Optometry, University of Benin, Benin 300283, Nigeria.

Department of Ophthalmology, Africa Eye Laser Centre Ltd, Benin 300105, Nigeria.

出版信息

World J Methodol. 2025 Dec 20;15(4):101033. doi: 10.5662/wjm.v15.i4.101033.

Abstract

BACKGROUND

Dry eye disease (DED) represents a multifactorial condition characterized by ocular discomfort and visual disturbances. The management of DED relies heavily on accurate diagnosis to tailor effective treatments. Diagnostic approaches encompass both subjective and objective assessments.

AIM

To review the diagnostic methods used in the process of dry eye disease management.

METHODS

A comprehensive review of diagnostic approaches for dry eye was performed using scientific databases. Studies published within the last four years were considered. Studies were excluded if a full text was absent or the article was not written in English. Articles were assessed for relevancy, and a total of 107 studies were selected. The selection method used a systematic methodology, which guaranteed an exhaustive assessment of the diagnostic techniques reported in current literature. The study adheres to principles for systematic reviews ensuring dependability and accuracy. The studies were assessed for emphasize on both novel traditional and diagnostic methods for dry eye disease management.

RESULTS

Key objective tests include tear break-up time, which evaluates tear film stability; fluorescein and lissamine green staining, which assess ocular surface damage and inflammation; tear osmolarity measurement, indicative of tear film quality; and tear volume assessment Schirmer's test, which evaluates tear production. Advanced imaging techniques such as optical coherence tomography and meibography offer detailed anatomical insights into the ocular surface and meibomian glands, aiding in the diagnosis of underlying structural abnormalities. Moreover, emerging technologies such as matrix metalloproteinase-9 testing and inflammatory biomarkers provide additional diagnostic precision, particularly in identifying inflammatory components of DED.

CONCLUSION

Integrating a combination of subjective and objective diagnostic tools allows clinicians to comprehensively assess the condition, tailor treatment plans, and monitor therapeutic efficacy. Continued advancements in diagnostic technologies promise to enhance our understanding and management of this prevalent ocular condition.

摘要

背景

干眼症(DED)是一种多因素疾病,其特征为眼部不适和视觉障碍。干眼症的管理在很大程度上依赖于准确诊断以制定有效的治疗方案。诊断方法包括主观和客观评估。

目的

回顾干眼症管理过程中使用的诊断方法。

方法

使用科学数据库对干眼症的诊断方法进行全面综述。考虑过去四年内发表的研究。如果没有全文或文章不是用英文撰写,则排除该研究。评估文章的相关性,共选择了107项研究。选择方法采用系统方法,确保对当前文献中报道的诊断技术进行详尽评估。该研究遵循系统综述的原则,以确保可靠性和准确性。评估这些研究对干眼症管理的新型传统诊断方法和诊断方法的强调。

结果

关键的客观测试包括评估泪膜稳定性的泪膜破裂时间;评估眼表损伤和炎症的荧光素和丽丝胺绿染色;指示泪膜质量的泪液渗透压测量;以及评估泪液分泌的泪液量评估(Schirmer试验)。光学相干断层扫描和睑板腺造影等先进成像技术可提供眼表和睑板腺的详细解剖学见解,有助于诊断潜在的结构异常。此外,基质金属蛋白酶-9检测和炎症生物标志物等新兴技术提供了额外的诊断精度,特别是在识别干眼症的炎症成分方面。

结论

综合使用主观和客观诊断工具可使临床医生全面评估病情、制定治疗方案并监测治疗效果。诊断技术的持续进步有望增强我们对这种常见眼部疾病的理解和管理。

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本文引用的文献

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