Department of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy.
Eye Clinic, Catania University San Marco Hospital, 95121 Catania, Italy.
Front Biosci (Landmark Ed). 2024 Aug 23;29(8):310. doi: 10.31083/j.fbl2908310.
This review explores the connection between the ocular surface microbiome and glaucoma, highlighting its impact on disease progression. Beginning with an overview of global glaucoma significance, it emphasizes the importance of understanding the cellular characteristics and microbiology of the ocular microbiome. A search was conducted on the PubMed and Cochrane Library databases using the phrase "ocular microbiome glaucoma". 0 records were returned from the Cochrane Library while 21 were returned from PubMed. A total of 21 results were retrieved from 2017 to 2024. This comprised one opinion paper, four original research articles, and 16 reviews. This review covered the anatomy of the ocular surface, advanced analysis methods, and the ocular microbiome. It also delved into dysbiosis in glaucoma, addressing altered microbial communities and their potential role in disease progression. The intricate interplay between the ocular microbiome and the host's immune system is explored, emphasizing crosstalk and inflammatory responses. The review concludes by discussing therapeutic implications, including modulating ocular microbiota and potential future treatment strategies. Understanding the microbiome in healthy and glaucomatous eyes can help researchers and clinicians in innovative approaches to ocular health.
本综述探讨了眼表微生物组与青光眼之间的联系，强调了其对疾病进展的影响。首先概述了全球青光眼的重要性，强调了了解眼表微生物组的细胞特征和微生物学的重要性。在 PubMed 和 Cochrane Library 数据库中使用短语“眼表微生物组与青光眼”进行了检索。Cochrane Library 未检索到记录，而 PubMed 检索到 21 条记录。从 2017 年到 2024 年，共检索到 21 项结果。其中包括一篇观点文章、四篇原始研究文章和 16 篇综述。本综述涵盖了眼表解剖、高级分析方法和眼表微生物组。它还探讨了青光眼的生态失调，涉及改变的微生物群落及其在疾病进展中的潜在作用。探讨了眼表微生物组与宿主免疫系统之间的复杂相互作用，强调了串扰和炎症反应。最后讨论了治疗意义，包括调节眼表微生物群和潜在的未来治疗策略。了解健康和青光眼眼中的微生物组可以帮助研究人员和临床医生在眼部健康方面进行创新方法。
