Ding Weisi, Shen Kai, Ren Wenhui, Tian Xue, Feng Yi
Department of Anesthesiology, Peking University People's Hospital, Beijing 100044, P.R. China.
Department of Gastroenterology Surgery, Peking University People's Hospital, Beijing 100044, P.R. China.
Exp Ther Med. 2025 Aug 14;30(4):199. doi: 10.3892/etm.2025.12949. eCollection 2025 Oct.
The aim of the present study was to investigate the association between the perioperative use of flurbiprofen axetil and the incidence of intestinal complications in patients undergoing radical colorectal surgery. For this purpose, the present retrospective study collected the medical records of patients who underwent their first radical colorectal surgery at Peking University People's Hospital (Beijing, China) between January 2018 and March 2022. Data included patient demographics, surgical details, intraoperative drug administration and postoperative intestinal complications. Univariate and multivariate analyses were performed to identify the risk factors for intestinal complications. A total of 1,364 patients were analyzed, of whom 89 (6.5%) developed postoperative intestinal complications, including ileus (45 patients, 3.3%), anastomotic leakage (40 patients, 2.9%) and celiac fistula (9 patients, 0.7%). In total, 5 patients experienced two types of intestinal complications. Age [odds ratio (OR), 1.022; 95% confidence interval (CI), 1.002-1.042; P=0.028], perioperative use of flurbiprofen axetil (OR, 2.072; 95% CI, 1.223-3.508; P=0.007), duration of surgery >3 h (OR, 2.032; 95% CI, 1.181-3.496; P=0.010) and intraoperative consumption of opioids (OR, 1.012; 95% CI, 1.003-1.022; P=0.009) were independent risk factors for postoperative intestinal complications. Overall, the present study demonstrates that age, the perioperative use of flurbiprofen axetil, the duration of surgery >3 h and high intraoperative consumption of opioids may increase the risk of developing postoperative intestinal complications in patients undergoing radical colorectal surgery.
本研究的目的是调查氟比洛芬酯围手术期使用与接受根治性结直肠手术患者肠道并发症发生率之间的关联。为此，本回顾性研究收集了2018年1月至2022年3月期间在北京大学人民医院（中国北京）接受首次根治性结直肠手术患者的病历。数据包括患者人口统计学资料、手术细节、术中用药及术后肠道并发症情况。进行单因素和多因素分析以确定肠道并发症的危险因素。共分析了1364例患者，其中89例（6.5%）发生术后肠道并发症，包括肠梗阻（45例，3.3%）、吻合口漏（40例，2.9%）和腹腔瘘（9例，0.7%）。共有5例患者出现两种类型的肠道并发症。年龄[比值比（OR），1.022；95%置信区间（CI），1.002 - 1.042；P = 0.028]、氟比洛芬酯围手术期使用（OR，2.072；95% CI，1.223 - 3.508；P = 0.007）、手术时间>3小时（OR，2.032；95% CI，1.181 - 3.496；P = 0.010）和术中阿片类药物用量（OR，1.012；95% CI，1.003 - 1.022；P = 0.009）是术后肠道并发症的独立危险因素。总体而言，本研究表明年龄、氟比洛芬酯围手术期使用、手术时间>3小时和术中高剂量阿片类药物使用可能增加接受根治性结直肠手术患者发生术后肠道并发症的风险。
