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1型格子状角膜营养不良患者使用环孢素滴眼液：病例报告

Cyclosporine eye drops in lattice corneal dystrophy type 1: case report.

作者信息

Al-Hawasli Hasan, Tarbouche Raghid

机构信息

Scientific Affairs Deputy Manager, Oubari Habboush Pharma, Damascus, Syria.

Eye and Ear Hospital, Damascus, Syria.

出版信息

Ann Med Surg (Lond). 2025 Jul 22;87(9):6127-6130. doi: 10.1097/MS9.0000000000003625. eCollection 2025 Sep.

DOI:10.1097/MS9.0000000000003625
PMID:40901133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12401456/
Abstract

INTRODUCTION AND IMPORTANCE

To report a successful treatment of lattice corneal dystrophy type 1 (LCD1) using topical cyclosporine (CsA) eye drop emulsion 0.05%.

CASE PRESENTATION

A 48-year-old female patient presented with bilateral LCD1characterized by corneal stromal lattice lines and visual symptoms. The patient was treated with topical CsA 0.05% twice daily for 3 months, followed by once daily for another 3 months.

CLINICAL DISCUSSION

Following treatment, the patient experienced a significant improvement in symptoms and resolution of corneal opacities in the treated eye.

CONCLUSION

This case report demonstrates the potential efficacy of topical CsA as a novel treatment option for LCD1, offering a noninvasive approach to manage symptoms and improve visual function. Further studies are needed to confirm these findings.

摘要

引言与重要性

报告使用0.05%环孢素（CsA）滴眼液乳剂成功治疗1型格子状角膜营养不良（LCD1）的病例。

病例介绍

一名48岁女性患者，双侧患有以角膜基质格子状线条和视觉症状为特征的LCD1。患者接受0.05% CsA滴眼液每日两次治疗3个月，随后每日一次再治疗3个月。

临床讨论

治疗后，患者症状显著改善，患眼角膜混浊消退。

结论

本病例报告证明局部使用CsA作为LCD1的一种新型治疗选择具有潜在疗效，为管理症状和改善视觉功能提供了一种非侵入性方法。需要进一步研究以证实这些发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd8b/12401456/7b2265efccff/ms9-87-6127-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd8b/12401456/b77a0d478631/ms9-87-6127-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd8b/12401456/dec73e083bcd/ms9-87-6127-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd8b/12401456/9c66f5dbc305/ms9-87-6127-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd8b/12401456/7b2265efccff/ms9-87-6127-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd8b/12401456/b77a0d478631/ms9-87-6127-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd8b/12401456/dec73e083bcd/ms9-87-6127-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd8b/12401456/9c66f5dbc305/ms9-87-6127-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd8b/12401456/7b2265efccff/ms9-87-6127-g004.jpg

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本文引用的文献

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Classic lattice corneal dystrophy: a brief review and summary of treatment modalities.经典格子状角膜营养不良：简要回顾及治疗方法总结。
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A case of lattice corneal dystrophy type 1 with bilateral Mooren's ulcer.1型格子状角膜营养不良合并双侧蚕蚀性角膜溃疡1例。
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Corneal irregularity and visual function using anterior segment optical coherence tomography in TGFBI corneal dystrophy.
TGFBI 角膜营养不良的眼前节光学相干断层扫描的角膜不规则和视觉功能。
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Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes.角膜移植术后感染性角膜炎：流行病学、危险因素、管理及预后
Front Med (Lausanne). 2021 Jul 7;8:707242. doi: 10.3389/fmed.2021.707242. eCollection 2021.
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A Review of the Mechanism of Action of Cyclosporine A: The Role of Cyclosporine A in Dry Eye Disease and Recent Formulation Developments.环孢素A作用机制综述：环孢素A在干眼病中的作用及近期剂型发展
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Modulation of innate immunity by cyclosporine A.环孢素 A 对固有免疫的调节。
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Ocular Manifestations and Therapeutic Options in Patients with Familial Amyloid Polyneuropathy: A Systematic Review.家族性淀粉样多神经病患者的眼部表现及治疗选择：一项系统评价
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Cyclosporine ophthalmic emulsions for the treatment of dry eye: a review of the clinical evidence.用于治疗干眼症的环孢素眼用乳剂：临床证据综述
Clin Investig (Lond). 2015;5(3):267-285. doi: 10.4155/cli.14.135.
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Prevalence of corneal dystrophies in the United States: estimates from claims data.美国角膜营养不良的患病率：来自理赔数据的估计。
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