Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Department of Ophthalmology, Kanto Central Hospital for Public School Teachers, 6-25-1 Kamiyoga, Setagaya-ku, Tokyo, 158-8531, Japan.
Sci Rep. 2022 Aug 12;12(1):13759. doi: 10.1038/s41598-022-17738-3.
The purpose of this study was to evaluate corneal irregular astigmatism of patients with granular and lattice corneal dystrophy (GCD and LCD). 70 GCD, 35 LCD, and 81 control eyes were included. Anterior and posterior corneal topographic data obtained from anterior segment optical coherence tomography were expanded into four components via Fourier harmonic analysis. These components were compared with healthy eyes and the association between each component and best-corrected visual acuity (BCVA) was investigated. Anterior and posterior components increased in both GCD and LCD eyes. Anterior and posterior components of GCD2, anterior of LCD type 1 (LCD1), posterior of LCD type IIIA (LCD 3A), and type IV (LCD4) significantly increased. BCVA was significantly associated with anterior and posterior components in LCD eyes but not in GCD. The anterior components of LCD1, anterior and posterior of LCD3A, and posterior of LCD4 , were positively correlated with BCVA. As conclusions, in GCD eyes, anterior and posterior components differed from those of the control but BCVA was not significantly associated with them. In LCD eyes, the anterior and posterior components increased, and BCVA was significantly associated with the anterior and posterior components.
本研究旨在评估颗粒状和格子状角膜营养不良（GCD 和 LCD）患者的角膜不规则散光。纳入 70 例 GCD 患者、35 例 LCD 患者和 81 例对照组患者。应用眼前节光学相干断层扫描获得的前、后角膜地形图数据通过傅里叶谐波分析扩展为四个分量。将这些分量与正常眼进行比较，并研究各分量与最佳矫正视力（BCVA）的关系。在前 GCD 和 LCD 眼中，前、后分量均增加。GCD2 的前、后分量，LCD1 型的前分量，LCD3A 型和 IV 型（LCD4）的后分量显著增加。在 LCD 眼中，BCVA 与前、后分量显著相关，但在 GCD 眼中不相关。LCD1 的前分量、LCD3A 的前、后分量和 LCD4 的后分量与 BCVA 呈正相关。总之，在 GCD 眼中，前、后分量与对照组不同，但与 BCVA 无显著相关性。在 LCD 眼中，前、后分量增加，BCVA 与前、后分量显著相关。
