Zhu Fengyi, Zhou Hai, Li Weizheng
YunFu People's Hospital, Yunfu, China.
Ann Med Surg (Lond). 2025 Jul 14;87(9):6045-6051. doi: 10.1097/MS9.0000000000003569. eCollection 2025 Sep.
Ovarian tumors are relatively rare in children and adolescent females, with mixed sex-cord-stromal tumors being a specific subtype that has a low incidence and is associated with DICER1 gene mutations.
This case report describes a 14-year-old female patient diagnosed with a mixed sex-cord-stromal tumor associated with a DICER1 gene mutation, who had a rapid recurrence. The patient did not receive standardized chemotherapy after the initial surgery, and the tumor recurred within 6 months, leading to a second surgery and chemotherapy. One year of follow-up showed no recurrence.
This case emphasizes the complexity and biological behavior of mixed sex-cord-stromal tumors, providing important differential diagnostic insights for clinical practice. Moreover, with only three cases of recurrence reported globally, it is crucial for clinicians to take this into consideration.
The management experience from this case provides important references for future related research and clinical practice.
卵巢肿瘤在儿童和青少年女性中相对少见，其中混合性性索间质肿瘤是一种特定亚型，发病率低且与DICER1基因突变相关。
本病例报告描述了一名14岁女性患者，被诊断为与DICER1基因突变相关的混合性性索间质肿瘤，该肿瘤迅速复发。患者在初次手术后未接受标准化化疗，肿瘤在6个月内复发，导致二次手术及化疗。一年的随访显示无复发。
本病例强调了混合性性索间质肿瘤的复杂性和生物学行为，为临床实践提供了重要的鉴别诊断见解。此外，全球仅报告了3例复发病例，临床医生对此加以考虑至关重要。
该病例的治疗经验为未来相关研究和临床实践提供了重要参考。
