Sun Xin, Shi Xiao-Wei, Han Lei, Zhang Yi-Fan, Xu Yang, Lu Yu-Cheng
Medical College, Linyi University, Linyi 276000, Shandong Province, China.
Department of Biobank, Linyi People's Hospital, Linyi 276000, Shandong Province, China.
World J Clin Oncol. 2025 Aug 24;16(8):107490. doi: 10.5306/wjco.v16.i8.107490.
Periplocin, periplocymarin and periplogenin are the main active components of . The most cytotoxic constituent of , periplocin is an alpha cardiac glycoside with a steroid core and an unsaturated five-membered lactone ring structure. Periplocymarin is a secondary alpha cardiac glycoside, which is produced by removing one molecule of glucose from periplocin, and periplogenin is the glycosidic portion and the basic unit of periplocin and periplocymarin. These three cardiac glycosides, by virtue of their unique pharmacological activities and mechanisms of action, mediate signaling pathways, mainly the retinoblastoma and p53 signaling pathways, and regulate cell cycle proteins, thereby hindering the proliferation of cancer cells and altering the cell cycle process. These glycosides also regulate caspase proteins by mediating endogenous and exogenous pathways, thereby inducing the apoptosis of cancer cells. This minireview focuses on the inhibitory effects of periplocin, periplocymarin and periplogenin on cancer, and explores their potential antitumor mechanisms.
杠柳毒苷、杠柳次苷和杠柳苷元是[植物名称]的主要活性成分。杠柳毒苷是[植物名称]中细胞毒性最强的成分，它是一种具有甾体核心和不饱和五元内酯环结构的α-强心苷。杠柳次苷是一种二级α-强心苷，由杠柳毒苷去除一分子葡萄糖产生，杠柳苷元是杠柳毒苷和杠柳次苷的糖苷部分及基本单元。这三种强心苷凭借其独特的药理活性和作用机制，介导信号通路，主要是视网膜母细胞瘤和p53信号通路，并调节细胞周期蛋白，从而阻碍癌细胞增殖并改变细胞周期进程。这些糖苷还通过介导内源性和外源性途径调节半胱天冬酶蛋白，从而诱导癌细胞凋亡。本综述聚焦于杠柳毒苷、杠柳次苷和杠柳苷元对癌症的抑制作用，并探讨其潜在的抗肿瘤机制。
