Baker Claire, Chalmers James D
Division of Respiratory Medicine and Gastroenterology, School of Medicine, University of Dundee, Dundee, UK.
ERJ Open Res. 2025 Sep 1;11(5). doi: 10.1183/23120541.01131-2024. eCollection 2025 Sep.
Bronchiectasis is a chronic respiratory condition characterised by irreversible dilation of the bronchi, leading to recurrent respiratory infections and chronic inflammation. Bacterial infections have been well-recognised as contributors to disease progression as well as potent inducers of exacerbations for decades. However, recent studies have indicated that viruses are present in up to 50% of exacerbations, raising questions over the role viruses may play in bronchiectasis. Despite the evidence of their presence, the role of viral infections in bronchiectasis remains largely underexplored. Understanding how viruses impact bronchiectasis is crucial in providing patients with better care and treatment strategies. Given the persistent threat of viral infections, as highlighted by the coronavirus disease 2019 (COVID-19) pandemic, this review aims to provide an overview of the current knowledge surrounding viruses in bronchiectasis, how they may trigger exacerbations and insights from other chronic respiratory conditions where the role of viruses is better understood.
支气管扩张症是一种慢性呼吸道疾病，其特征为支气管不可逆扩张，导致反复呼吸道感染和慢性炎症。几十年来，细菌感染一直被公认为是疾病进展的促成因素以及病情加重的强效诱导因素。然而，最近的研究表明，高达50%的病情加重发作中存在病毒，这引发了人们对病毒在支气管扩张症中可能扮演的角色的质疑。尽管有证据表明病毒存在，但病毒感染在支气管扩张症中的作用在很大程度上仍未得到充分探索。了解病毒如何影响支气管扩张症对于为患者提供更好的护理和治疗策略至关重要。鉴于2019年冠状病毒病（COVID-19）大流行凸显的病毒感染的持续威胁，本综述旨在概述目前关于支气管扩张症中病毒的知识、它们可能如何引发病情加重发作，以及从其他对病毒作用有更深入了解的慢性呼吸道疾病中获得的见解。
