Wiradinata William, Subali Anita Dominique, Aditya Muhammad Reva
Faculty of Medicine, Universitas Brawijaya, Malang East Java, Indonesia.
Naibonat General Hospital Kupang Regency, Indonesia.
US Cardiol. 2025 Aug 20;19:e17. doi: 10.15420/usc.2024.66. eCollection 2025.
Exercise-induced long QT may mimic congenital long QT syndrome (LQTS), risking misdiagnosis and unnecessary treatment. This scoping review explores its reversibility through detraining and differentiation from congenital LQTS. A systematic search of five databases identified six studies involving 196 subjects. Results showed that exercise-induced long QT is reversible, with QT intervals normalizing after detraining, typically over 1-6 months. Unlike congenital LQTS, affected athletes often lacked genetic mutations or family histories linked to the condition. The difference between congenital LQTS and exercise-induced long QT lies in the reversibility of QT interval prolongation. In those with exercise-induced long QT, the prolonged QT interval would return to normal levels with detraining, unlike in congenital LQTS. Further long-term follow-up is needed to assess the potential arrhythmic risk associated with re-exposure to intensive training. Additionally, negative genetic testing and absence of family history do not entirely exclude congenital LQTS nor indicate benignity, emphasizing the need for careful clinical assessment beyond these factors.
运动诱发的长QT间期可能会模仿先天性长QT综合征（LQTS），存在误诊和不必要治疗的风险。本综述探讨了通过停止训练使其恢复正常以及与先天性LQTS进行鉴别诊断的可能性。通过对五个数据库进行系统检索，确定了六项涉及196名受试者的研究。结果显示，运动诱发的长QT间期是可逆的，停止训练后QT间期通常在1至6个月内恢复正常。与先天性LQTS不同，受影响的运动员通常没有与该病相关的基因突变或家族病史。先天性LQTS与运动诱发的长QT间期的区别在于QT间期延长的可逆性。在运动诱发长QT间期的患者中，与先天性LQTS不同，QT间期延长会随着停止训练而恢复到正常水平。需要进一步进行长期随访，以评估再次进行高强度训练可能带来的心律失常风险。此外，基因检测结果为阴性且没有家族病史并不能完全排除先天性LQTS，也不表明病情良性，这强调了除这些因素外还需要进行仔细的临床评估。
