Zhu Deng-Sheng, Zhang Zhen, Huang Xiao-Rui, Zhang Jing-Zhao, Zhang Zhi-Wei, Guo Xin-Yi, Zheng Huan, Guo Tong, Yu Ya-Hong
Department of Biliopancreatic Surgery, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430000, Hubei Province, China.
World J Gastroenterol. 2025 Aug 21;31(31):109994. doi: 10.3748/wjg.v31.i31.109994.
Textbook outcome (TO), an emerging composite metric for surgical quality assessment, has recently gained recognition for evaluating perioperative results. Laparoscopic transcystic common bile duct exploration (LTCBDE) has become a widely adopted minimally invasive technique for treating cholecystolithiasis with choledocholithiasis. Despite its growing clinical application, TO has not yet been formally defined for LTCBDE, nor have its failure-associated risk factors been systematically examined.
To define TO for LTCBDE, establish standardized criteria, and identify risk factors for TO failure logistic regression.
A retrospective cohort of 388 patients who underwent LTCBDE in combination with laparoscopic cholecystectomy at the Department of Biliopancreatic Surgery, Tongji Hospital, from January 2018 to October 2024, was analyzed. The study delineated TO criteria for LTCBDE, calculated the rate of TO achievement, and employed logistic regression to determine independent predictors of TO failure.
TO was defined as the absence of the following seven criteria: Conversion to open surgery, postoperative complications (Clavien-Dindo grade ≥ 2), biliary leakage (International Study Group of Pancreatic Surgery/International Study Group of Liver Surgery grade B/C), delayed removal of drainage tube (> 4 days), postoperative interventions, prolonged length of stay (> 7 days), and 30-day readmission or mortality. Among 388 patients, 276 (71.1%) achieved TO. The primary causes of TO failure included delayed removal of drainage tube (94 cases, 83.9%), prolonged length of stay (50 cases, 44.6%). Multivariate analysis revealed four independent risk factors for TO failure: Preoperative endoscopic retrograde cholangiopancreatography ( = 0.022), advanced age ( = 0.010), prolonged anesthesia time ( < 0.001), and elevated preoperative alkaline phosphatase levels ( = 0.048).
These findings suggest that applying the concept of TO to LTCBDE enhances surgical quality evaluation and supports early identification of high-risk patients, facilitating personalized clinical decisions and optimizing individual management.
教科书式结局(TO)是一种新兴的用于评估手术质量的综合指标,最近在评估围手术期结果方面获得了认可。腹腔镜经胆囊管胆总管探查术(LTCBDE)已成为治疗胆囊结石合并胆总管结石广泛采用的微创技术。尽管其临床应用日益广泛,但TO尚未针对LTCBDE进行正式定义,其与失败相关的危险因素也未得到系统研究。
为LTCBDE定义TO,建立标准化标准,并通过逻辑回归确定TO失败的危险因素。
对2018年1月至2024年10月在同济大学胆胰外科接受LTCBDE联合腹腔镜胆囊切除术的388例患者进行回顾性队列分析。该研究划定了LTCBDE的TO标准,计算了TO达成率,并采用逻辑回归确定TO失败的独立预测因素。
TO被定义为不存在以下七个标准:转为开放手术、术后并发症(Clavien-Dindo分级≥2级)、胆漏(国际胰腺手术研究组/国际肝脏手术研究组B/C级)、引流管拔除延迟(>4天)、术后干预、住院时间延长(>7天)以及30天再入院或死亡。在388例患者中,276例(71.1%)达成TO。TO失败的主要原因包括引流管拔除延迟(94例,83.9%)、住院时间延长(50例,44.6%)。多因素分析显示TO失败的四个独立危险因素:术前内镜逆行胰胆管造影(P = 0.022)、高龄(P = 0.010)、麻醉时间延长(P < 0.001)以及术前碱性磷酸酶水平升高(P = 0.048)。
这些发现表明,将TO概念应用于LTCBDE可提高手术质量评估,并有助于早期识别高危患者,促进个性化临床决策并优化个体管理。