Jadhav Vishwajeet, Verma Priyanka, Chandak Ashok, Basu Sandip
Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Parel, Mumbai.
Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Clin Nucl Med. 2025 Aug 25. doi: 10.1097/RLU.0000000000006113.
Cutaneous angiosarcoma of the scalp is a rare, highly aggressive malignant tumor. A 67-year-old man with initial presentation of intermittent facial puffiness, periorbital swelling, and a gradually increasing painless ulcerative lesion on the right side of his forehead, and biopsy-proven cutaneous angiosarcoma, underwent 18F-FDG-PET/CT for initial staging. FDG-PET/CT demonstrated increased tracer uptake in the scalp and facial regions, encompassing periorbital and perinasal areas. 68Ga-NODAGA-RGD-PET/CT (imaging marker of increased angiogenesis) revealed enhanced uptake at the same regions, without evidence of bone or brain parenchyma involvement. Unlike FDG, 68Ga-NODAGA-RGD, with no physiological uptake in the brain, demonstrates promise as an advanced diagnostic and treatment-monitoring tool for evaluation of scalp/brain involvement.
头皮皮肤血管肉瘤是一种罕见的、高度侵袭性的恶性肿瘤。一名67岁男性，最初表现为间歇性面部肿胀、眶周水肿，右侧前额有一个逐渐增大的无痛性溃疡性病变，活检证实为皮肤血管肉瘤，接受了18F-FDG-PET/CT进行初始分期。FDG-PET/CT显示头皮和面部区域示踪剂摄取增加，包括眶周和鼻周区域。68Ga-NODAGA-RGD-PET/CT（血管生成增加的成像标志物）显示相同区域摄取增强，无骨或脑实质受累证据。与FDG不同，68Ga-NODAGA-RGD在脑内无生理性摄取，有望作为评估头皮/脑受累情况的先进诊断和治疗监测工具。
