不同比密的低色素红细胞对钾的膜通透性

Permeability of membrane to potassium in hypochromic red cells with different specific density.

作者信息

Vettore L, De Matteis M C, Antonini L

出版信息

Acta Haematol. 1977;58(3):145-51. doi: 10.1159/000207821.

DOI:10.1159/000207821

Abstract

In hypochromic anaemias (heterozygous beta-thalassaemia and iron deficiency anaemia) ligher red cells lose more K+ than heavier ones, following incubation at 37 degrees C for 24 h. Both in the light and heavy fractions two subpopulations of cells with different permeability to K+ can be separated by a new centrifugation after incubation. On the basis of the results, a relationship between K+ permeability and probability of survival in hypochromic cells is suggested.

摘要

在低色素性贫血（杂合子β地中海贫血和缺铁性贫血）中，较轻的红细胞在37℃孵育24小时后比重大的红细胞丢失更多的钾离子。在孵育后，通过新的离心方法，无论是轻组分还是重组分中的细胞都可分离出对钾离子具有不同通透性的两个亚群。基于这些结果，提出了低色素性细胞中钾离子通透性与存活概率之间的关系。