Balageas Anna-Chloé, Vercouillie Johnny, Arlicot Nicolas, Dupont Anne-Claire, Santiago Ribeiro Maria-Joao
Centre Mémoire Ressources et Recherche CHU Tours, Tours, France.
UMR, iBrain, Université de Tours, Inserm, Tours, France.
Front Med (Lausanne). 2025 Aug 19;12:1653232. doi: 10.3389/fmed.2025.1653232. eCollection 2025.
We report the case of a 75-year-old patient with a clinically isolated and stable amnestic syndrome over fifteen years, despite a cerebrospinal fluid (CSF) profile strongly consistent with Alzheimer's disease (AD). Serial PET imaging over two years showed only limited amyloid accumulation, no significant tau deposition, no hypometabolism, and no neuroinflammation. This case illustrates a striking dissociation between biomarker positivity and clinical progression, raising important questions about individual resilience and the prognostic value of AD biomarkers in isolation.
我们报告了一例75岁的患者，其患有临床上孤立且稳定的遗忘综合征长达15年，尽管脑脊液（CSF）检查结果与阿尔茨海默病（AD）高度相符。两年的连续PET成像显示仅有有限的淀粉样蛋白积累，无明显的tau蛋白沉积，无代谢减低，也无神经炎症。该病例说明了生物标志物阳性与临床进展之间存在显著分离，这引发了关于个体复原力以及孤立的AD生物标志物的预后价值的重要问题。
