Butenko Konstantin, Roediger Jan, Al-Fatly Bassam, Li Ningfei, Dembek Till A, Gan Yifei, Zhu Guan-Yu, Zhang Jianguo, Kühn Andrea A, Horn Andreas
Movement Disorders and Neuromodulation Unit, Department of Neurology with Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10117, Germany.
Center for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Brain Commun. 2025 Aug 19;7(5):fcaf301. doi: 10.1093/braincomms/fcaf301. eCollection 2025.
Comparatively high excitability of myelinated fibres suggests that they represent a major mediator of deep brain stimulation effects. Such effects can be modelled using different levels of abstraction, ranging from simple electric field estimates to complex multicompartment axon models. In this study, we explored three metrics to evaluate axonal activation: electric field magnitudes, electric field projections and pathway activation modelling. Furthermore, in order to account for variability in axonal morphology, these metrics were computed in a probabilistic fashion. To showcase and illustrate their relevance, we retrospectively analysed a dataset of 15 Parkinson's disease patients, who were stimulated in the subthalamic nucleus in bipolar mode. High similarity of activation patterns was observed for the electric field metrics, but not for pathway activation modelling, which might be attributed to its ability to capture stimulation's polarity. Nevertheless, all three metrics associated motor improvement with activation of motor pallidosubthalamic and hyperdirect pathways. To make these probabilistic approaches accessible to the community, the modelling and statistical framework was implemented in the openly available Lead-DBS toolbox.
有髓纤维相对较高的兴奋性表明它们是深部脑刺激效应的主要介导者。可以使用不同层次的抽象来模拟这种效应，从简单的电场估计到复杂的多节段轴突模型。在本研究中，我们探索了三种评估轴突激活的指标：电场强度、电场投影和通路激活建模。此外，为了考虑轴突形态的变异性，这些指标以概率方式计算。为了展示并说明它们的相关性，我们回顾性分析了15例帕金森病患者的数据集，这些患者在双极模式下接受丘脑底核刺激。电场指标观察到激活模式的高度相似性，但通路激活建模未观察到，这可能归因于其捕捉刺激极性的能力。然而，所有这三个指标都将运动改善与运动苍白球丘脑底核和超直接通路的激活联系起来。为了使这些概率方法能够为社区所用，建模和统计框架在公开可用的Lead-DBS工具箱中实现。
