口服含有HASPIN抑制剂香豆雌酚的豆芽可提高男性血液中的睾酮水平。
Oral Ingestion of Bean Sprouts Containing the HASPIN Inhibitor Coumestrol Increased Blood Testosterone Levels in Men.
作者信息
Kakazu Keisuke, Tsujimura Akira, Miyagawa Yasushi, Takezawa Kentaro, Kobayashi Kazuhiro, Yoshimura Ryoji, Nakajima Kensuke, Kamiya Seitaro, Tanaka Hiromitsu
机构信息
Laboratory of Molecular Biology, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo 859-3298, Nagasaki, Japan.
Department of Urology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu 279-0021, Chiba, Japan.
出版信息
Biology (Basel). 2025 Jul 22;14(8):907. doi: 10.3390/biology14080907.
Extending healthy lifespans is an important public health goal in societies with a long life expectancy. Late-onset hypogonadism (LOH), a condition associated with an age-related decrease in testosterone level, contributes to the onset of various diseases. Previously, we demonstrated that the oral ingestion of bean sprouts rich in the HASPIN inhibitor coumestrol increased blood testosterone levels in mice. In the present study, we showed that the oral ingestion of bean sprouts also led to increased blood testosterone levels in humans. These results suggested that bean sprouts, which are rich in coumestrol, have potential as a dietary intervention for the treatment of LOH.
在预期寿命较长的社会中，延长健康寿命是一项重要的公共卫生目标。迟发性性腺功能减退（LOH）是一种与年龄相关的睾酮水平下降有关的病症，会导致各种疾病的发生。此前，我们证明口服富含HASPIN抑制剂香豆雌酚的豆芽可提高小鼠的血液睾酮水平。在本研究中，我们表明口服豆芽也会导致人类血液睾酮水平升高。这些结果表明，富含香豆雌酚的豆芽有潜力作为治疗LOH的饮食干预措施。
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