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Too big to fail? Comparing effect sizes of MDMA assisted therapy to unmasking bias.

作者信息

Szigeti Balázs, Bradley Ellen R, Woolley Joshua

机构信息

Translational psychedelic research group, Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, USA.

Centre for Psychedelic Research, Imperial College London, London, UK.

出版信息

Psychopharmacology (Berl). 2025 Sep 4. doi: 10.1007/s00213-025-06886-9.

DOI:10.1007/s00213-025-06886-9
PMID:40906191
Abstract
摘要

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本文引用的文献

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Expectancy Effects in Psychedelic Trials.迷幻药试验中的期待效应。
Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 May;9(5):512-521. doi: 10.1016/j.bpsc.2024.02.004. Epub 2024 Feb 20.
2
Molecular imaging of bacterial outer membrane vesicles based on bacterial surface display.基于细菌表面展示的细菌外膜囊泡的分子成像
Sci Rep. 2023 Oct 31;13(1):18752. doi: 10.1038/s41598-023-45628-9.
3
MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial.MDMA 辅助治疗中重度 PTSD：一项随机、安慰剂对照的 3 期试验。
Nat Med. 2023 Oct;29(10):2473-2480. doi: 10.1038/s41591-023-02565-4. Epub 2023 Sep 14.
4
Ketamine treatment for depression: a review.氯胺酮治疗抑郁症：综述
Discov Ment Health. 2022;2(1):9. doi: 10.1007/s44192-022-00012-3. Epub 2022 Apr 15.
5
Great Expectations: recommendations for improving the methodological rigor of psychedelic clinical trials.高期望：改善迷幻药临床试验方法严谨性的建议。
Psychopharmacology (Berl). 2022 Jun;239(6):1989-2010. doi: 10.1007/s00213-022-06123-7. Epub 2022 Apr 1.
6
Impact of midazolam vs. saline on effect size estimates in controlled trials of ketamine as a rapid-acting antidepressant.咪达唑仑与生理盐水对氯胺酮作为快速抗抑郁药的对照试验中效应量估计值的影响。
Neuropsychopharmacology. 2019 Jun;44(7):1233-1238. doi: 10.1038/s41386-019-0317-8. Epub 2019 Jan 17.
7
Pharmacotherapy for post-traumatic stress disorder: systematic review and meta-analysis.创伤后应激障碍的药物治疗：系统评价和荟萃分析。
Br J Psychiatry. 2015 Feb;206(2):93-100. doi: 10.1192/bjp.bp.114.148551.
8
Systematic review of blinding assessment in randomized controlled trials in schizophrenia and affective disorders 2000-2010.2000-2010 年精神分裂症和情感障碍随机对照试验中盲法评估的系统评价。
Psychother Psychosom. 2013;82(3):152-60. doi: 10.1159/000346144. Epub 2013 Mar 21.
9
A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression.一项关于 N-甲基-D-天冬氨酸拮抗剂治疗难治性双相抑郁的随机附加试验。
Arch Gen Psychiatry. 2010 Aug;67(8):793-802. doi: 10.1001/archgenpsychiatry.2010.90.
10
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.一项关于N-甲基-D-天冬氨酸拮抗剂治疗难治性重度抑郁症的随机试验。
Arch Gen Psychiatry. 2006 Aug;63(8):856-64. doi: 10.1001/archpsyc.63.8.856.