Lukulay Mariama, Debnath Pradipta, Anton Christopher G, Li Yinan, Prasanphanich Adam F, Sharp Susan E, Zhang Bin, Trout Andrew T, Morin Cara E
University of Cincinnati, Cincinnati, United States.
Cincinnati Childrens Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.
Pediatr Radiol. 2025 Sep 4. doi: 10.1007/s00247-025-06381-5.
Fentanyl is used in some pediatric practices with a goal of suppressing 18F-fluorodeoxyglucose (18F-FDG) uptake in brown fat.
The purpose of this study was to examine the frequency, intensity, and distribution of brown fat uptake in warmed children undergoing 18F-FDG PET/CT with and without premedication with fentanyl. MATERIALS AND METHODS: This retrospective study included children (< 18 years old) who underwent 18F-FDG-PET from 2014 to 2024 at a center that routinely warms patients and uses intravenous fentanyl for brown fat suppression for most patients. Three radiologists assessed the presence, intensity, and location of brown fat uptake. Chi-square test and two-sample t-test were used to compare the demographics and brown fat uptake between premedication and non-premedication groups.
Among 873 18F-FDG-PETs, 595 (68%) were performed with fentanyl premedication and warming and 278 (32%) were conducted with warming alone. Brown fat uptake was observed in 46 (5.3%) FDG-PETs, 32/595 (5.4%) in the premedicated group and 14/278 (5.0%) in the non-premedicated group (P = 0.83). No differences were found in brown fat intensity or location based on premedication status. Age (14.5 vs. 8.5; P < 0.001) and BMI (20.1 vs. 17.7; P < 0.001) were significantly associated with brown fat uptake.
Fentanyl premedication does not significantly affect brown fat uptake frequency, intensity, or location in warmed children undergoing 18F-FDG-PET.
在一些儿科医疗实践中使用芬太尼，目的是抑制棕色脂肪对18F-氟脱氧葡萄糖（18F-FDG）的摄取。
本研究旨在检查在接受18F-FDG PET/CT检查的体温升高的儿童中，使用和不使用芬太尼进行预处理时棕色脂肪摄取的频率、强度和分布情况。
这项回顾性研究纳入了2014年至2024年在一家中心接受18F-FDG-PET检查的儿童（<18岁），该中心常规为患者保暖，且大多数患者使用静脉注射芬太尼来抑制棕色脂肪摄取。三名放射科医生评估棕色脂肪摄取的存在、强度和位置。采用卡方检验和两样本t检验比较预处理组和未预处理组的人口统计学特征及棕色脂肪摄取情况。
在873例18F-FDG-PET检查中，595例（68%）在使用芬太尼预处理并保暖的情况下进行，278例（32%）仅进行了保暖。在46例（5.3%）FDG-PET检查中观察到棕色脂肪摄取，预处理组为32/595（5.4%），未预处理组为14/278（5.0%）（P = 0.83）。根据预处理状态，棕色脂肪强度或位置未发现差异。年龄（14.5对8.5；P < 0.001）和BMI（20.1对17.7；P < 0.001）与棕色脂肪摄取显著相关。
在接受18F-FDG-PET检查且体温升高的儿童中，芬太尼预处理对棕色脂肪摄取频率、强度或位置没有显著影响。
