Steinberg Jeffrey D, Vogel Wouter, Vegt Erik
1 Mouse Clinic for Cancer and Aging (MCCA) Imaging Unit, Netherlands Cancer Institute, Amsterdam, Netherlands.
2 Department of Nuclear Medicine, Netherlands Cancer Institute, Amsterdam, Netherlands.
Br J Radiol. 2017 Jul;90(1075):20170093. doi: 10.1259/bjr.20170093. Epub 2017 Jun 7.
Brown fat can exhibit high uptake of fluorine-18 fludeoxyglucose (F-FDG) on positron emission tomography (PET) and interferes with interpretation of the scan. The goal of this study was to identify factors that may influence brown adipose tissue (BAT) activation.
A retrospective study of F-FDG PET scans was performed using a database of 15,109 PET/CT reports. BAT activation reported by nuclear medicine physicians and factors influencing BAT activation were gathered. The data were analyzed using in-house software.
The total reported BAT activation was 3.6%. BAT activation was reported significantly more often in patients who were female (p < 0.0001), younger (p < 0.0001), with lower body mass index (p < 0.0001), with lower blood glucose levels (p = 0.01), indicated for breast cancer (p = 0.004), not administered chemotherapy recently before the scan (p < 0.0001) and shown to have BAT activation in a previous scan (p < 0.0001). BAT activation was also reported significantly more for lower outdoor temperatures (p < 0.0001) and for late morning scans than for afternoon (p = 0.005) and early morning (p = 0.001) scans.
This retrospective study of 15,109 scans highlights multiple factors contributing to BAT activation on F-FDG PET. The identification of new factors influencing BAT and confirmation of previously identified factors with a larger data set can be used to more accurately identify patients at risk for BAT activation so that prevention strategies can be implemented. Advances in knowledge: This study presents new factors associated with higher incidence of BAT activation, such as time of day, previous BAT activation and breast cancer. Conversely, recent chemotherapy was associated with reduced incidence of BAT activation.
棕色脂肪在正电子发射断层扫描（PET）中可表现出对氟-18氟脱氧葡萄糖（F-FDG）的高摄取，并干扰扫描结果的解读。本研究的目的是确定可能影响棕色脂肪组织（BAT）激活的因素。
利用一个包含15109份PET/CT报告的数据库，对F-FDG PET扫描进行回顾性研究。收集核医学医师报告的BAT激活情况以及影响BAT激活的因素。使用内部软件对数据进行分析。
报告的BAT总激活率为3.6%。女性患者（p<0.0001）、较年轻患者（p<0.0001）、体重指数较低患者（p<0.0001）、血糖水平较低患者（p=0.01）、因乳腺癌进行检查的患者（p=0.004）、扫描前近期未接受化疗的患者（p<0.0001）以及之前扫描显示有BAT激活的患者（p<0.0001）中，BAT激活的报告明显更频繁。室外温度较低时（p<0.0001）以及上午晚些时候扫描时，BAT激活的报告也明显多于下午（p=0.005）和清晨（p=0.001）扫描时。
这项对15109次扫描的回顾性研究突出了导致F-FDG PET上BAT激活的多个因素。确定影响BAT的新因素并通过更大数据集确认先前确定的因素，可用于更准确地识别有BAT激活风险的患者，从而实施预防策略。知识进展：本研究提出了与BAT激活发生率较高相关的新因素，如一天中的时间、先前的BAT激活和乳腺癌。相反，近期化疗与BAT激活发生率降低相关。
