Park Hannah, Yoo Jin, Kim Ji Su, Park Do-Yang, Park Bumhee, Kim Hyun Jun
Department of Otorhinolaryngology - Head and Neck Surgery, Ajou University School of Medicine, 164 Worldcup Street, Yeongtong-gu, Suwon, 16499, Korea.
Office of Biostatistics, Medical Research Collaborating Center, Ajou Research Institute for Innovative Medicine, Ajou University School of Medicine, Suwon, Korea.
Sleep Breath. 2025 Sep 4;29(5):281. doi: 10.1007/s11325-025-03455-4.
The objectives of this study were to monitor transcutaneous and end-tidal partial pressures of CO simultaneously during polysomnography, determine the advantages and disadvantages of each method, and identify relevant factors that can affect the results.
This cross-sectional study enrolled 55 adults who underwent polysomnography at the Ajou University Hospital Sleep Center between February 2021 and September 2022. They were volunteers who spontaneously breathed room air. Polysomnography reports, including those of CO monitoring, of all participants were reviewed and analyzed by sleep experts. Generalized Estimation Evaluation, Bon Ferroni Post Hoc and multivariable regression analysis were used for statistical analysis.
Throughout all sleep stages, the mean, highest, and lowest values of end-tidal and transcutaneous partial pressure of CO showed significant differences. The mean transcutaneous partial pressure was higher than the mean end-tidal partial pressure by 2.53 mmHg. The apnea index, apnea-hypopnea index, and height were significant factors affecting the difference between the mean transcutaneous and end-tidal partial pressure of CO. As the obstructive sleep apnea grade increased, the mean end-tidal CO partial pressure value decreased. Two patients had hypoventilation; one met the criteria based on the transcutaneous partial pressure of CO and the other met those based on the end-tidal partial pressure of CO.
During diagnostic sleep studies, the application of both transcutaneous and end-tidal measurements is suggested for stable and accurate monitoring of partial pressure of CO and complementary analysis.
本研究的目的是在多导睡眠监测期间同时监测经皮和呼气末二氧化碳分压，确定每种方法的优缺点，并识别可能影响结果的相关因素。
这项横断面研究纳入了2021年2月至2022年9月在韩国亚洲大学医院睡眠中心接受多导睡眠监测的55名成年人。他们是自主呼吸室内空气的志愿者。所有参与者的多导睡眠监测报告，包括二氧化碳监测报告，均由睡眠专家进行审查和分析。采用广义估计评估、Bon Ferroni事后检验和多变量回归分析进行统计分析。
在所有睡眠阶段，呼气末和经皮二氧化碳分压的平均值、最高值和最低值均存在显著差异。经皮二氧化碳分压的平均值比呼气末二氧化碳分压的平均值高2.53 mmHg。呼吸暂停指数、呼吸暂停低通气指数和身高是影响经皮和呼气末二氧化碳分压平均值差异的重要因素。随着阻塞性睡眠呼吸暂停分级的增加，呼气末二氧化碳分压的平均值降低。两名患者存在通气不足；一名根据经皮二氧化碳分压符合标准，另一名根据呼气末二氧化碳分压符合标准。
在诊断性睡眠研究中，建议同时应用经皮和呼气末测量方法，以稳定、准确地监测二氧化碳分压并进行补充分析。
